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HCPCS Level II · Procedures and professional services (temporary)

G0659Drug test(s), definitive, utilizing drug identification methods able to identify individual drugs and distinguish between structural isomers (but not necessarily stereoisomers), including but not limited to gc/ms (any type, single or tandem) and lc/ms (any type, single or tandem), excluding immunoassays (e.g., ia, eia, elisa, emit, fpia) and enzymatic methods (e.g., alcohol dehydrogenase), performed without method or drug-specific calibration, without matrix-matched quality control material, or without use of stable isotope or other universally recognized internal standard(s) for each drug, drug metabolite or drug class per specimen; qualitative or quantitative, all sources, includes specimen validity testing, per day, any number of drug classes

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Source: CMS HCPCS quarterly update, October 2026. Page updated September 29, 2026.

About G0659

G0659 is an HCPCS Level II code in the G series (procedures and professional services (temporary)), describing drug test(s), definitive, utilizing drug identification methods able to identify individual drugs and distinguish between structural isomers (but not necessarily stereoisomers), including but not limited to gc/ms (any type, single or tandem) and lc/ms (any type, single or tandem), excluding immunoassays (e.g., ia, eia, elisa, emit, fpia) and enzymatic methods (e.g., alcohol dehydrogenase), performed without method or drug-specific calibration, without matrix-matched quality control material, or without use of stable isotope or other universally recognized internal standard(s) for each drug, drug metabolite or drug class per specimen; qualitative or quantitative, all sources, includes specimen validity testing, per day, any number of drug classes.

It was added to HCPCS effective 01/01/2017.

Its Medicare coverage code is "C", meaning coverage is left to the Medicare contractor's judgment.

Details

Short description
Drug test def simple all cl
Date added
01/01/2017
Action effective
01/01/2017
BETOS
T1H

Related G06xx codes

Common questions about G0659

Is HCPCS G0659 still valid?

Yes. G0659 is active in the CMS October 2026 HCPCS file.

Does Medicare cover G0659?

Its coverage code is "C": coverage is left to the Medicare contractor's judgment. Check the local coverage determination for your region.