ICD-10-CM 2027
ICD-10 code for cross syndrome
From the official ICD-10-CM alphabetic index entry “Cross syndrome”. Page updated September 29, 2026.
About coding cross syndrome
The ICD-10-CM code for cross syndrome is E70.328 (Other oculocutaneous albinism).
Within E70.32, choose E70.328 (Other oculocutaneous albinism) only when documentation doesn't support a more specific option: Tyrosinase negative oculocutaneous albinism (E70.320), Tyrosinase positive oculocutaneous albinism (E70.321) and unspecified (E70.329).
As a secondary diagnosis it is a CC (complication or comorbidity), which can move an inpatient stay into the "with CC" MS-DRG of its family, unless the principal diagnosis excludes it.
In MS-DRG v44.0, it is part of the grouping logic for DRG 642 (Inborn and Other Disorders of Metabolism, relative weight 1.3219), in MDC 10 (Endocrine, Nutritional and Metabolic Diseases and Disorders), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.
Common questions about cross syndrome ICD-10 codes
What is the ICD-10 code for cross syndrome?
- E70.328 — Other oculocutaneous albinism.
Is E70.328 billable?
- Yes. E70.328 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can E70.328 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict E70.328 as a principal diagnosis.
Is E70.328 a CC or MCC?
- E70.328 is a CC (complication or comorbidity) under MS-DRG v44.0, unless excluded by the principal diagnosis.