ICD-10-CM 2027
ICD-10 code for generalized colibacillosis
Sepsis due to Escherichia coli [E. coli]
From the official ICD-10-CM alphabetic index entry “Colibacillosis › generalized”. Page updated September 29, 2026.
About coding generalized colibacillosis
The ICD-10-CM code for generalized colibacillosis is A41.51 (Sepsis due to Escherichia coli [E. coli]).
Within A41.5 (sepsis due to other Gram-negative organisms), A41.51 is specifically for sepsis due to Escherichia coli [E. coli]. Related codes cover gram-negative sepsis, unspecified (A41.50), sepsis due to Pseudomonas (A41.52), sepsis due to Serratia (A41.53), sepsis due to Acinetobacter baumannii (A41.54) and other Gram-negative sepsis (A41.59).
Code first: , if applicable, postprocedural sepsis (T81.44-), sepsis due to central venous catheter (T80.211-), sepsis during labor (O75.3), sepsis following abortion, ectopic or molar pregnancy (O03.37, O03.87, O04.87, O07.37, O08.82) and 2 more.
As a secondary diagnosis it is an MCC (major complication or comorbidity), which can move an inpatient stay into the highest-paying "with MCC" MS-DRG of its family, unless the principal diagnosis excludes it.
Common questions about generalized colibacillosis ICD-10 codes
What is the ICD-10 code for generalized colibacillosis?
- A41.51 — Sepsis due to Escherichia coli [E. coli].
Is A41.51 billable?
- Yes. A41.51 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can A41.51 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict A41.51 as a principal diagnosis.
Is A41.51 a CC or MCC?
- A41.51 is an MCC (major complication or comorbidity) under MS-DRG v44.0, unless excluded by the principal diagnosis.