ICD-10-CM 2027
ICD-10 code for Hand-foot syndrome
From the official ICD-10-CM alphabetic index entry “Hand-foot syndrome”. Page updated September 29, 2026.
About coding Hand-foot syndrome
The ICD-10-CM code for Hand-foot syndrome is L27.1 (Localized skin eruption due to drugs and medicaments taken internally).
Within L27 (dermatitis due to substances taken internally), L27.1 is specifically for localized skin eruption due to drugs and medicaments taken internally. Related codes cover generalized skin eruption due to drugs and medicaments taken internally (L27.0), dermatitis due to ingested food (L27.2), dermatitis due to other substances taken internally (L27.8) and dermatitis due to unspecified substance taken internally (L27.9).
Use an additional code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5).
It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.
Common questions about Hand-foot syndrome ICD-10 codes
What is the ICD-10 code for Hand-foot syndrome?
- L27.1 — Localized skin eruption due to drugs and medicaments taken internally.
Is L27.1 billable?
- Yes. L27.1 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can L27.1 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict L27.1 as a principal diagnosis.
Is L27.1 a CC or MCC?
- No. L27.1 is neither a CC nor an MCC under MS-DRG v44.0.