ICD-10-CM 2027
ICD-10 code for Leukemoid reaction
From the official ICD-10-CM alphabetic index entry “Leukemoid reaction”. Page updated September 29, 2026.
About coding Leukemoid reaction
The ICD-10-CM code for Leukemoid reaction is D72.823 (Leukemoid reaction).
Within D72.82 (elevated white blood cell count), D72.823 is specifically for Leukemoid reaction. Related codes cover Lymphocytosis (symptomatic) (D72.820), Monocytosis (symptomatic) (D72.821), Plasmacytosis (D72.822), Basophilia (D72.824), Bandemia (D72.825), other elevated white blood cell count (D72.828) and unspecified (D72.829).
It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.
In MS-DRG v44.0, it is part of the grouping logic for DRG 814 (Reticuloendothelial and Immunity Disorders with MCC, relative weight 2.0729), DRG 815 (Reticuloendothelial and Immunity Disorders with CC, relative weight 1.0444) and DRG 816 (Reticuloendothelial and Immunity Disorders without CC/MCC, relative weight 0.7381), in MDC 16 (Diseases and Disorders of the Blood and Blood Forming Organs and Immunological Disorders), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.
Common questions about Leukemoid reaction ICD-10 codes
What is the ICD-10 code for Leukemoid reaction?
- D72.823 — Leukemoid reaction.
Is D72.823 billable?
- Yes. D72.823 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can D72.823 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict D72.823 as a principal diagnosis.
Is D72.823 a CC or MCC?
- No. D72.823 is neither a CC nor an MCC under MS-DRG v44.0.