ICD-10-CM 2027
ICD-10 code for MELAS syndrome
From the official ICD-10-CM alphabetic index entry “MELAS syndrome”. Page updated September 29, 2026.
About coding MELAS syndrome
The ICD-10-CM code for MELAS syndrome is E88.41 (MELAS syndrome).
Within E88.4 (mitochondrial metabolism disorders), E88.41 is specifically for MELAS syndrome. Related codes cover mitochondrial metabolism disorder, unspecified (E88.40), MERRF syndrome (E88.42), disorders of mitochondrial tRNA synthetases (E88.43) and other mitochondrial metabolism disorders (E88.49).
Use an additional code for: codes for associated conditions.
As a secondary diagnosis it is a CC (complication or comorbidity), which can move an inpatient stay into the "with CC" MS-DRG of its family, unless the principal diagnosis excludes it.
Common questions about MELAS syndrome ICD-10 codes
What is the ICD-10 code for MELAS syndrome?
- E88.41 — MELAS syndrome.
Is E88.41 billable?
- Yes. E88.41 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can E88.41 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict E88.41 as a principal diagnosis.
Is E88.41 a CC or MCC?
- E88.41 is a CC (complication or comorbidity) under MS-DRG v44.0, unless excluded by the principal diagnosis.