ICD-10-CM 2027
ICD-10 code for nutritional anasarca
Unspecified severe protein-calorie malnutrition
From the official ICD-10-CM alphabetic index entry “Anasarca › nutritional”. Page updated September 29, 2026.
About coding nutritional anasarca
The ICD-10-CM code for nutritional anasarca is E43 (Unspecified severe protein-calorie malnutrition).
As a secondary diagnosis it is an MCC (major complication or comorbidity), which can move an inpatient stay into the highest-paying "with MCC" MS-DRG of its family, unless the principal diagnosis excludes it.
In MS-DRG v44.0, it is part of the grouping logic for DRG 640 (Miscellaneous Disorders of Nutrition, Metabolism, Fluids and Electrolytes with MCC, relative weight 1.3395), DRG 641 (Miscellaneous Disorders of Nutrition, Metabolism, Fluids and Electrolytes without MCC, relative weight 0.7865), DRG 791 (Prematurity with Major Problems, relative weight 4.1075) and DRG 793 (Full Term Neonate with Major Problems, relative weight 4.2195), in MDC 10 (Endocrine, Nutritional and Metabolic Diseases and Disorders) and MDC 15 (Newborns and Other Neonates with Conditions Originating in the Perinatal Period), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.
It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.
Common questions about nutritional anasarca ICD-10 codes
What is the ICD-10 code for nutritional anasarca?
- E43 — Unspecified severe protein-calorie malnutrition.
Is E43 billable?
- Yes. E43 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can E43 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict E43 as a principal diagnosis.
Is E43 a CC or MCC?
- E43 is an MCC (major complication or comorbidity) under MS-DRG v44.0, unless excluded by the principal diagnosis.