ICD-10-CM 2027
ICD-10 code for phenylketonuria screening
From the official ICD-10-CM alphabetic index entry “Screening (for) › phenylketonuria”. Page updated September 29, 2026.
About coding phenylketonuria screening
The ICD-10-CM code for phenylketonuria screening is Z13.228 (Encounter for screening for other metabolic disorders).
Within Z13.22, choose Z13.228 (other metabolic disorders) only when documentation doesn't support a more specific option: lipoid disorders (Z13.220).
It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.
In MS-DRG v44.0, it is part of the grouping logic for DRG 795 (Normal Newborn, relative weight 0.2022) and DRG 951 (Other Factors Influencing Health Status, relative weight 0.5577), in MDC 15 (Newborns and Other Neonates with Conditions Originating in the Perinatal Period) and MDC 23 (Factors Influencing Health Status and Other Contacts with Health Services), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.
Common questions about phenylketonuria screening ICD-10 codes
What is the ICD-10 code for phenylketonuria screening?
- Z13.228 — Encounter for screening for other metabolic disorders.
Is Z13.228 billable?
- Yes. Z13.228 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can Z13.228 be used as a principal diagnosis?
- No. It is not acceptable as the principal diagnosis for an inpatient stay; it may be reported as a secondary diagnosis.
Is Z13.228 a CC or MCC?
- No. Z13.228 is neither a CC nor an MCC under MS-DRG v44.0.