ICD-10-CM 2027
ICD-10 code for Proteolysis
Disseminated intravascular coagulation [defibrination syndrome]
From the official ICD-10-CM alphabetic index entry “Proteolysis, pathologic”. Page updated September 29, 2026.
About coding Proteolysis
The ICD-10-CM code for Proteolysis is D65 (Disseminated intravascular coagulation [defibrination syndrome]).
Don't report D65 together with the conditions in its Excludes1 note: in newborn (P60) and pregnancy, childbirth and the puerperium (O45.0, O46.0, O67.0, O72.3).
The conditions in its Excludes2 note aren't part of D65, but may be coded alongside it if the patient has both: abortion or ectopic or molar pregnancy (O00-O07, O08.1).
As a secondary diagnosis it is an MCC (major complication or comorbidity), which can move an inpatient stay into the highest-paying "with MCC" MS-DRG of its family, unless the principal diagnosis excludes it.
Don't confuse with (Excludes1 for D65)
Common questions about Proteolysis ICD-10 codes
What is the ICD-10 code for Proteolysis?
- D65 — Disseminated intravascular coagulation [defibrination syndrome].
Is D65 billable?
- Yes. D65 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can D65 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict D65 as a principal diagnosis.
Is D65 a CC or MCC?
- D65 is an MCC (major complication or comorbidity) under MS-DRG v44.0, unless excluded by the principal diagnosis.