ICD-10-CM 2027
ICD-10 code for septic shock
R65.21
Severe sepsis with septic shock
From the official ICD-10-CM alphabetic index entry “Shock › septic (due to severe sepsis)”. Page updated September 29, 2026.
About coding septic shock
The ICD-10-CM code for septic shock is R65.21 (Severe sepsis with septic shock).
Within R65.2 (severe sepsis), R65.21 is specifically for severe sepsis with septic shock. Related codes cover without septic shock (R65.20).
Don't report R65.21 together with the conditions in its Excludes1 note: postprocedural septic shock (T81.12-).
As a secondary diagnosis it is an MCC (major complication or comorbidity), which can move an inpatient stay into the highest-paying "with MCC" MS-DRG of its family, unless the principal diagnosis excludes it.
Don't confuse with (Excludes1 for R65.21)
- postprocedural septic shock (T81.12-)
Common questions about septic shock ICD-10 codes
What is the ICD-10 code for septic shock?
- R65.21 — Severe sepsis with septic shock.
Is R65.21 billable?
- Yes. R65.21 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can R65.21 be used as a principal diagnosis?
- No. It is not acceptable as the principal diagnosis for an inpatient stay; it may be reported as a secondary diagnosis.
Is R65.21 a CC or MCC?
- R65.21 is an MCC (major complication or comorbidity) under MS-DRG v44.0, unless excluded by the principal diagnosis.