ICD-10-CM 2027
ICD-10 code for supplemental oxygen dependence
From the official ICD-10-CM alphabetic index entry “Dependence (on) (syndrome) › supplemental oxygen”. Page updated September 29, 2026.
About coding supplemental oxygen dependence
The ICD-10-CM code for supplemental oxygen dependence is Z99.81 (Dependence on supplemental oxygen).
Within Z99.8 (dependence on other enabling machines and devices), Z99.81 is specifically for dependence on supplemental oxygen. Related codes cover other enabling machines and devices (Z99.89).
It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.
In MS-DRG v44.0, it is part of the grouping logic for DRG 951 (Other Factors Influencing Health Status, relative weight 0.5577), in MDC 23 (Factors Influencing Health Status and Other Contacts with Health Services), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.
Common questions about supplemental oxygen dependence ICD-10 codes
What is the ICD-10 code for supplemental oxygen dependence?
- Z99.81 — Dependence on supplemental oxygen.
Is Z99.81 billable?
- Yes. Z99.81 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can Z99.81 be used as a principal diagnosis?
- No. It is not acceptable as the principal diagnosis for an inpatient stay; it may be reported as a secondary diagnosis.
Is Z99.81 a CC or MCC?
- No. Z99.81 is neither a CC nor an MCC under MS-DRG v44.0.