Skip to content
Dx

ICD-10-PCS 2027 procedure code

3E0133ZIntroduction of Anti-inflammatory into Subcutaneous Tissue, Percutaneous Approach

✓ Valid for 2027

Short description: Introduction of Anti-inflammatory into Subcu, Perc Approach

Code unchanged since ICD-10-PCS took effect on October 1, 2015. Source: official FY2027 ICD-10-PCS release from CMS. Page updated September 29, 2026. About our data

About 3E0133Z

3E0133Z is the ICD-10-PCS code for a introduction procedure on the subcutaneous tissue using a percutaneous approach with anti-inflammatory. In ICD-10-PCS, introduction means putting in or on a therapeutic, diagnostic, nutritional, physiological, or prophylactic substance except blood or blood products.

In plain terms, this corresponds to injection of locally acting therapeutic substance into other soft tissue, injection of locally acting therapeutic substance into other soft tissue and injection of steroid, the ICD-9-CM procedure titles it maps to (83.98, 83.98 and 99.23).

For a different body part, codes include 3E0233Z (muscle), 3E0333Z (peripheral vein), 3E0433Z (central vein), 3E0533Z (peripheral artery), 3E0633Z (central artery), 3E0933Z (nose) and 22 more.

With a different device, use 3E0134Z (serum, toxoid and vaccine), 3E0136Z (nutritional substance), 3E0137Z (electrolytic and water balance substance), 3E013BZ (anesthetic agent), 3E013HZ (radioactive substance), 3E013KZ (other diagnostic substance) and 2 more.

It doesn't appear in the MS-DRG procedure index, so on its own it doesn't change the DRG assignment.

It has been valid since ICD-10-PCS took effect on October 1, 2015.

What each character means

1. Section
3Administration
2. Body System
EPhysiological Systems and Anatomical Regions
3. Operation
0Introduction

Putting in or on a therapeutic, diagnostic, nutritional, physiological, or prophylactic substance except blood or blood products

4. Body System / Region
1Subcutaneous Tissue
5. Approach
3Percutaneous

Entry, by puncture or minor incision, of instrumentation through the skin or mucous membrane and any other body layers necessary to reach the site of the procedure

6. Substance
3Anti-inflammatory
7. Qualifier
ZNo Qualifier

Other versions of this procedure

ICD-9-CM equivalent

Converter →
  • 83.98Injection of locally acting therapeutic substance into other soft tissueapproximate, combination
  • 83.98Injection of locally acting therapeutic substance into other soft tissueapproximate
  • 99.23Injection of steroidapproximate, combination

From the CMS 2018 General Equivalence Mappings (GEMs), the final GEMs release.

Code history

  1. 2016
  2. 2017
  3. 2018
  4. 2019
  5. 2020
  6. 2021
  7. 2022
  8. 2023
  9. 2024
  10. 2025
  11. 2026
  12. 2027
  • FY2016 (effective 10/1/2015): Added (first year of ICD-10-CM)
  • No changes since FY2016.

Common questions about 3E0133Z

Is 3E0133Z a valid ICD-10-PCS code for 2027?

Yes. 3E0133Z is valid for inpatient procedures from October 1, 2026 through September 30, 2027.

What is the ICD-9 procedure code for 3E0133Z?

The CMS GEMs map 3E0133Z to ICD-9-CM 83.98 (Injection of locally acting therapeutic substance into other soft tissue), 83.98 (Injection of locally acting therapeutic substance into other soft tissue) and 99.23 (Injection of steroid).