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ICD-10-PCS 2027 procedure code

3E03316Introduction of Recombinant Human-activated Protein C into Peripheral Vein, Percutaneous

✓ Valid for 2027

Short description: Introduction of Recomb Protein C into Periph Vein, Perc

Code unchanged since ICD-10-PCS took effect on October 1, 2015. Source: official FY2027 ICD-10-PCS release from CMS. Page updated September 29, 2026. About our data

About 3E03316

3E03316 is the ICD-10-PCS code for a introduction procedure on the peripheral vein using a percutaneous approach with thrombolytic (qualifier: recombinant human-activated protein c). In ICD-10-PCS, introduction means putting in or on a therapeutic, diagnostic, nutritional, physiological, or prophylactic substance except blood or blood products.

In plain terms, this corresponds to infusion of drotrecogin alfa (activated), the ICD-9-CM procedure title it maps to (00.11).

For a different body part, codes include 3E04316 (central vein), 3E05316 (peripheral artery), 3E06316 (central artery), 3E07316 (coronary artery) and 3E08316 (heart).

The same procedure with a different approach is coded 3E03016 (open).

It doesn't appear in the MS-DRG procedure index, so on its own it doesn't change the DRG assignment.

It has been valid since ICD-10-PCS took effect on October 1, 2015.

What each character means

1. Section
3Administration
2. Body System
EPhysiological Systems and Anatomical Regions
3. Operation
0Introduction

Putting in or on a therapeutic, diagnostic, nutritional, physiological, or prophylactic substance except blood or blood products

4. Body System / Region
3Peripheral Vein
5. Approach
3Percutaneous

Entry, by puncture or minor incision, of instrumentation through the skin or mucous membrane and any other body layers necessary to reach the site of the procedure

6. Substance
1Thrombolytic
7. Qualifier
6Recombinant Human-activated Protein C

Other versions of this procedure

Different approach

Different qualifier

ICD-9-CM equivalent

Converter →
  • 00.11Infusion of drotrecogin alfa (activated)approximate

From the CMS 2018 General Equivalence Mappings (GEMs), the final GEMs release.

Code history

  1. 2016
  2. 2017
  3. 2018
  4. 2019
  5. 2020
  6. 2021
  7. 2022
  8. 2023
  9. 2024
  10. 2025
  11. 2026
  12. 2027
  • FY2016 (effective 10/1/2015): Added (first year of ICD-10-CM)
  • No changes since FY2016.

Common questions about 3E03316

Is 3E03316 a valid ICD-10-PCS code for 2027?

Yes. 3E03316 is valid for inpatient procedures from October 1, 2026 through September 30, 2027.

What is the ICD-9 procedure code for 3E03316?

The CMS GEMs map 3E03316 to ICD-9-CM 00.11 (Infusion of drotrecogin alfa (activated)).