ICD-9-CM diagnosis code (retired)
648.33 — Drug dependence of mother, antepartum condition or complication
ICD-9-CM was replaced by ICD-10 on October 1, 2015. These are the ICD-10-CM equivalents from the CMS General Equivalence Mappings.
About ICD-9-CM 648.33
648.33 is an ICD-9-CM diagnosis code for drug dependence of mother, antepartum condition or complication. ICD-9-CM was retired for U.S. claims on October 1, 2015, when ICD-10-CM took over.
The CMS General Equivalence Mappings translate it to 3 ICD-10-CM codes, such as O99.321 (Drug use complicating pregnancy, first trimester), O99.322 (Drug use complicating pregnancy, second trimester) and O99.323 (Drug use complicating pregnancy, third trimester). All of these are approximate matches, so review the record to pick the right one.
ICD-10-CM equivalents
Common questions about 648.33
GEMs are a translation aid, not a substitute for coding from the record. The 2027 ICD-10 code set has changed since the last GEMs release in 2018. Page updated September 29, 2026.