ICD-9-CM procedure code (retired)
99.21 — Injection of antibiotic
About ICD-9-CM 99.21
99.21 is an ICD-9-CM procedure code for injection of antibiotic. ICD-9-CM was retired for U.S. claims on October 1, 2015, when ICD-10-PCS took over.
The CMS General Equivalence Mappings translate it to 11 ICD-10-PCS codes, such as 3E00X29 (Introduction of Other Anti-infective into Skin and Mucous Membranes, External Approach), 3E01329 (Introduction of Other Anti-infective into Subcutaneous Tissue, Percutaneous Approach) and 3E02329 (Introduction of Other Anti-infective into Muscle, Percutaneous Approach). All of these are approximate matches, so review the record to pick the right one.
ICD-10-PCS equivalents
- 3E00X29Introduction of Other Anti-infective into Skin and Mucous Membranes, External Approachapproximate
- 3E01329Introduction of Other Anti-infective into Subcutaneous Tissue, Percutaneous Approachapproximate
- 3E02329Introduction of Other Anti-infective into Muscle, Percutaneous Approachapproximate
- 3E03329Introduction of Other Anti-infective into Peripheral Vein, Percutaneous Approachapproximate
- 3E04329Introduction of Other Anti-infective into Central Vein, Percutaneous Approachapproximate
- 3E05329Introduction of Other Anti-infective into Peripheral Artery, Percutaneous Approachapproximate
- 3E06329Introduction of Other Anti-infective into Central Artery, Percutaneous Approachapproximate
- XW03321Introduction of Ceftazidime-Avibactam Anti-infective into Peripheral Vein, Percutaneous Approach, New Technology Group 1approximate
- XW03341Introduction of Isavuconazole Anti-infective into Peripheral Vein, Percutaneous Approach, New Technology Group 1approximate
- XW04321Introduction of Ceftazidime-Avibactam Anti-infective into Central Vein, Percutaneous Approach, New Technology Group 1approximate
- XW04341Introduction of Isavuconazole Anti-infective into Central Vein, Percutaneous Approach, New Technology Group 1approximate
Common questions about 99.21
What is the ICD-10 code for ICD-9 99.21?
- The GEMs map 99.21 to ICD-10-PCS 3E00X29, 3E01329, 3E02329, 3E03329, 3E04329, 3E05329 and 5 more.
GEMs are a translation aid, not a substitute for coding from the record. The 2027 ICD-10 code set has changed since the last GEMs release in 2018. Page updated September 29, 2026.