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ICD-10-CM 2027 diagnosis code

A41.4Sepsis due to anaerobes

✓ Billable / specificMCC — major complication/comorbidity

A41.4 is a valid, billable ICD-10-CM code for sepsis due to anaerobes. It can be reported on claims for dates of service from October 1, 2026 – September 30, 2027.

Code unchanged since ICD-10-CM took effect on October 1, 2015. Source: official FY2027 ICD-10-CM release from CDC/NCHS and CMS. Page updated September 29, 2026. About our data

About A41.4

A41.4 is the ICD-10-CM diagnosis code for sepsis due to anaerobes. It belongs to category A41 (other sepsis), block A30-A49 (other bacterial diseases) and chapter 1 (certain infectious and parasitic diseases). It is billable, so it can be reported on its own for dates of service from October 1, 2026 through September 30, 2027.

Within A41 (other sepsis), A41.4 is specifically for sepsis due to anaerobes. Related codes cover sepsis due to Staphylococcus aureus (A41.0), sepsis due to other specified staphylococcus (A41.1), sepsis due to unspecified staphylococcus (A41.2), sepsis due to Hemophilus influenzae (A41.3), sepsis due to other Gram-negative organisms (A41.5), other specified sepsis (A41.8) and sepsis, unspecified organism (A41.9).

Don't report A41.4 together with the conditions in its Excludes1 note: gas gangrene (A48.0).

Code first: , if applicable, postprocedural sepsis (T81.44-), sepsis due to central venous catheter (T80.211-), sepsis during labor (O75.3), sepsis following abortion, ectopic or molar pregnancy (O03.37, O03.87, O04.87, O07.37, O08.82) and 2 more.

As a secondary diagnosis it is an MCC (major complication or comorbidity), which can move an inpatient stay into the highest-paying "with MCC" MS-DRG of its family, unless the principal diagnosis excludes it.

In MS-DRG v44.0, it is part of the grouping logic for DRG 791 (Prematurity with Major Problems, relative weight 4.1075), DRG 793 (Full Term Neonate with Major Problems, relative weight 4.2195), DRG 870 (Septicemia or Severe Sepsis with MV >96 Hours, relative weight 6.9408), DRG 871 (Septicemia or Severe Sepsis without MV >96 Hours with MCC, relative weight 1.932), DRG 872 (Septicemia or Severe Sepsis without MV >96 Hours without MCC, relative weight 1.0066), DRG 974 (HIV with Major Related Condition with MCC, relative weight 3.0506) and 2 more, in MDC 15 (Newborns and Other Neonates with Conditions Originating in the Perinatal Period), MDC 18 (Infectious and Parasitic Diseases, Systemic or Unspecified Sites) and MDC 25 (Human Immunodeficiency Virus Infections), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.

It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.

Before ICD-10, this condition was coded in ICD-9-CM as 038.3 (septicemia due to anaerobes) and 995.91 (sepsis).

Coding notes

Excludes1Not coded here — never report together with this code

Notes that apply from higher levels

Instructions written at a parent level also apply to A41.4.

› From A41 Other sepsis
Excludes1
  • bacteremia NOS (R78.81)
  • neonatal (P36.-)
  • puerperal sepsis (O85)
  • streptococcal sepsis (A40.-)
Excludes2
  • sepsis (due to) (in) actinomycotic (A42.7)
  • sepsis (due to) (in) anthrax (A22.7)
  • sepsis (due to) (in) candidal (B37.7)
  • sepsis (due to) (in) Erysipelothrix (A26.7)
  • sepsis (due to) (in) extraintestinal yersiniosis (A28.2)
  • sepsis (due to) (in) gonococcal (A54.86)
  • sepsis (due to) (in) herpesviral (B00.7)
  • sepsis (due to) (in) listerial (A32.7)
  • sepsis (due to) (in) melioidosis (A24.1)
  • sepsis (due to) (in) meningococcal (A39.2-A39.4)
  • sepsis (due to) (in) plague (A20.7)
  • sepsis (due to) (in) tularemia (A21.7)
  • toxic shock syndrome (A48.3)
Code first

Broader instructions also apply from Chapter 1: Certain infectious and parasitic diseases.

Alphabetic index entries

6 entries

Terms in the official ICD-10-CM index that lead to A41.4.

MS-DRG v44.0 grouping

All DRGs →

Inpatient MS-DRGs this diagnosis can group to, as the principal or a secondary diagnosis, depending on the rest of the claim.

MDC 15 · Newborns and Other Neonates with Conditions Originating in the Perinatal Period

MDC 15 · Newborns and Other Neonates with Conditions Originating in the Perinatal Period

ICD-9-CM equivalent

Converter →
  • 038.3Septicemia due to anaerobesapproximate, combination
  • 995.91Sepsisapproximate, combination

From the CMS 2018 General Equivalence Mappings (GEMs), the final GEMs release.

Code history

  1. 2016
  2. 2017
  3. 2018
  4. 2019
  5. 2020
  6. 2021
  7. 2022
  8. 2023
  9. 2024
  10. 2025
  11. 2026
  12. 2027
  • FY2016 (effective 10/1/2015): Added (first year of ICD-10-CM)
  • No changes since FY2016.

Common questions about A41.4

Is A41.4 billable?

Yes. A41.4 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).

Can A41.4 be used as a principal diagnosis?

Yes. The Medicare Code Editor doesn't restrict A41.4 as a principal diagnosis.

Is A41.4 a CC or MCC?

A41.4 is an MCC (major complication or comorbidity) under MS-DRG v44.0, unless excluded by the principal diagnosis.

What DRG does A41.4 group to?

A41.4 is used in the MS-DRG v44.0 logic for MS-DRG 791 (Prematurity with Major Problems), MS-DRG 793 (Full Term Neonate with Major Problems), MS-DRG 870 (Septicemia or Severe Sepsis with MV >96 Hours), MS-DRG 871 (Septicemia or Severe Sepsis without MV >96 Hours with MCC), MS-DRG 872 (Septicemia or Severe Sepsis without MV >96 Hours without MCC), MS-DRG 974 (HIV with Major Related Condition with MCC) and 2 more. Which one applies depends on whether it is the principal diagnosis and on the rest of the claim.

What is the ICD-9 code for A41.4?

The CMS General Equivalence Mappings map A41.4 to ICD-9-CM 038.3 and 995.91.