ICD-10-CM 2027 diagnosis code
A81.8Other atypical virus infections of central nervous system
A81.8 is a header code, so it can't be reported by itself. Choose one of the 4 more specific codes beneath it.
Code unchanged since ICD-10-CM took effect on October 1, 2015. Source: official FY2027 ICD-10-CM release from CDC/NCHS and CMS. Page updated September 29, 2026. About our data
About A81.8
A81.8 is the ICD-10-CM diagnosis code for other atypical virus infections of central nervous system. It belongs to category A81 (atypical virus infections of central nervous system), block A80-A89 (viral and prion infections of the central nervous system) and chapter 1 (certain infectious and parasitic diseases). It is a header code, so it can't be reported by itself; one of its 4 subcodes must be used instead.
Within A81, choose A81.8 (Other atypical virus infections of central nervous system) only when documentation doesn't support a more specific option: Creutzfeldt-Jakob disease (A81.0), subacute sclerosing panencephalitis (A81.1), progressive multifocal leukoencephalopathy (A81.2) and atypical virus infection of central nervous system, unspecified (A81.9).
To report this condition, pick the subcode that matches the documentation: A81.81 (Kuru), A81.82 (syndrome), A81.83 (insomnia) and A81.89 (system).
Use an additional code, if applicable, to identify: dementia with anxiety (F02.84, F02.A4, F02.B4, F02.C4), dementia with behavioral disturbance (F02.81-, F02.A1-, F02.B1-, F02.C1-), dementia with mood disturbance (F02.83, F02.A3, F02.B3, F02.C3), dementia with psychotic disturbance (F02.82, F02.A2, F02.B2, F02.C2), dementia without behavioral disturbance (F02.80, F02.A0, F02.B0, F02.C0) and 1 more.
It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.
Specific codes under A81.8
Notes that apply from higher levels
Instructions written at a parent level also apply to A81.8.
› From A81 Atypical virus infections of central nervous system
- diseases of the central nervous system caused by prions
- code, if applicable, to identify:
- dementia with anxiety (F02.84, F02.A4, F02.B4, F02.C4)
- dementia with behavioral disturbance (F02.81-, F02.A1-, F02.B1-, F02.C1-)
- dementia with mood disturbance (F02.83, F02.A3, F02.B3, F02.C3)
- dementia with psychotic disturbance (F02.82, F02.A2, F02.B2, F02.C2)
- dementia without behavioral disturbance (F02.80, F02.A0, F02.B0, F02.C0)
- mild neurocognitive disorder due to known physiological condition (F06.7-)
Broader instructions also apply from A80-A89 Viral and prion infections of the central nervous system and Chapter 1: Certain infectious and parasitic diseases.
Code history
- 2016
- 2017
- 2018
- 2019
- 2020
- 2021
- 2022
- 2023
- 2024
- 2025
- 2026
- 2027
- FY2016 (effective 10/1/2015): Added (first year of ICD-10-CM)
- No changes since FY2016.
Common questions about A81.8
Is A81.8 billable?
- No. A81.8 is a header code. Report one of its more specific subcodes instead.