B16.2Acute hepatitis B without delta-agent with hepatic coma

B16.2 is the ICD-10-CM diagnosis code for acute hepatitis B without delta-agent with hepatic coma. It belongs to category B16 (acute hepatitis B), block B15-B19 (viral hepatitis) and chapter 1 (certain infectious and parasitic diseases). It is billable, so it can be reported on its own for dates of service from October 1, 2026 through September 30, 2027.

Within B16, choose B16.2 (without delta-agent with hepatic coma) only when documentation doesn't support a more specific option: with delta-agent with hepatic coma (B16.0), with delta-agent without hepatic coma (B16.1) and without delta-agent and without hepatic coma (B16.9).

As a secondary diagnosis it is an MCC (major complication or comorbidity), which can move an inpatient stay into the highest-paying "with MCC" MS-DRG of its family, unless the principal diagnosis excludes it.

In MS-DRG v44.0, it is part of the grouping logic for DRG 441 (Disorders of Liver Except Malignancy, Cirrhosis or Alcoholic Hepatitis with MCC, relative weight 1.8219), DRG 442 (Disorders of Liver Except Malignancy, Cirrhosis or Alcoholic Hepatitis with CC, relative weight 0.9602), DRG 443 (Disorders of Liver Except Malignancy, Cirrhosis or Alcoholic Hepatitis without CC/MCC, relative weight 0.6885), DRG 791 (Prematurity with Major Problems, relative weight 4.1075) and DRG 793 (Full Term Neonate with Major Problems, relative weight 4.2195), in MDC 07 (Diseases and Disorders of the Hepatobiliary System and Pancreas) and MDC 15 (Newborns and Other Neonates with Conditions Originating in the Perinatal Period), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.

It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.

Before ICD-10, this condition was coded in ICD-9-CM as 070.20 (viral hepatitis B with hepatic coma, acute or unspecified, without mention of hepatitis delta).