C54.0Malignant neoplasm of isthmus uteri

C54.0 is the ICD-10-CM diagnosis code for malignant neoplasm of isthmus uteri. It belongs to category C54 (malignant neoplasm of corpus uteri), block C51-C58 (malignant neoplasms of female genital organs) and chapter 2 (neoplasms). It is billable, so it can be reported on its own for dates of service from October 1, 2026 through September 30, 2027.

Within C54 (malignant neoplasm of corpus uteri), C54.0 is specifically for malignant neoplasm of isthmus uteri. Related codes cover endometrium (C54.1), myometrium (C54.2), fundus uteri (C54.3), overlapping sites of corpus uteri (C54.8) and unspecified (C54.9).

It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.

In MS-DRG v44.0, it is part of the grouping logic for DRG 731 (Uterine and Adnexa Procedures for Malignancy with MCC, relative weight 3.5478), DRG 732 (Uterine and Adnexa Procedures for Malignancy with CC, relative weight 1.9208), DRG 733 (Uterine and Adnexa Procedures for Malignancy without CC/MCC, relative weight 1.4324), DRG 754 (Malignancy, Female Reproductive System with MCC, relative weight 1.8092), DRG 755 (Malignancy, Female Reproductive System with CC, relative weight 1.149) and DRG 756 (Malignancy, Female Reproductive System without CC/MCC, relative weight 0.8645), in MDC 13 (Diseases and Disorders of the Female Reproductive System), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.

It is on the CMS list of diagnoses consistent only with female patients (the sex-conflict edit itself was retired in FY2025).

It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.

Before ICD-10, this condition was coded in ICD-9-CM as 182.1 (malignant neoplasm of isthmus).