ICD-10-CM 2027 diagnosis code
C92.42Acute promyelocytic leukemia, in relapse
C92.42 is a valid, billable ICD-10-CM code for acute promyelocytic leukemia, in relapse. It can be reported on claims for dates of service from October 1, 2026 – September 30, 2027.
Code unchanged since ICD-10-CM took effect on October 1, 2015. Source: official FY2027 ICD-10-CM release from CDC/NCHS and CMS. Page updated September 29, 2026. About our data
About C92.42
C92.42 is the ICD-10-CM diagnosis code for acute promyelocytic leukemia, in relapse. It belongs to category C92 (myeloid leukemia), block C81-C96 (malignant neoplasms of lymphoid, hematopoietic and related tissue) and chapter 2 (neoplasms). It is billable, so it can be reported on its own for dates of service from October 1, 2026 through September 30, 2027.
Within C92.4 (acute promyelocytic leukemia), C92.42 is specifically for acute promyelocytic leukemia, in relapse. Related codes cover not having achieved remission (C92.40) and in remission (C92.41).
As a secondary diagnosis it is a CC (complication or comorbidity), which can move an inpatient stay into the "with CC" MS-DRG of its family, unless the principal diagnosis excludes it.
In MS-DRG v44.0, it is part of the grouping logic for DRG 820 (Lymphoma and Leukemia with Major O.R. Procedures with MCC, relative weight 6.2481), DRG 821 (Lymphoma and Leukemia with Major O.R. Procedures with CC, relative weight 2.2023), DRG 822 (Lymphoma and Leukemia with Major O.R. Procedures without CC/MCC, relative weight 1.1272), DRG 834 (Acute Leukemia with MCC, relative weight 5.508), DRG 835 (Acute Leukemia with CC, relative weight 2.3031), DRG 836 (Acute Leukemia without CC/MCC, relative weight 1.1406) and 4 more, in MDC 17 (Myeloproliferative Diseases and Disorders, Poorly Differentiated Neoplasms), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.
It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.
Before ICD-10, this condition was coded in ICD-9-CM as 205.02 (acute myeloid leukemia, in relapse).
Notes that apply from higher levels
Instructions written at a parent level also apply to C92.42.
› From C92 Myeloid leukemia
Broader instructions also apply from C81-C96 Malignant neoplasms of lymphoid, hematopoietic and related tissue and Chapter 2: Neoplasms.
MS-DRG v44.0 grouping
All DRGs →Inpatient MS-DRGs this diagnosis can group to, as the principal or a secondary diagnosis, depending on the rest of the claim.
MDC 17 · Myeloproliferative Diseases and Disorders, Poorly Differentiated Neoplasms
MDC 17 · Myeloproliferative Diseases and Disorders, Poorly Differentiated Neoplasms
MDC 17 · Myeloproliferative Diseases and Disorders, Poorly Differentiated Neoplasms
- 837Chemotherapy with Acute Leukemia as Secondary Diagnosis or with High Dose Chemotherapy Agent with MCCRW 4.7124
- 838Chemotherapy with Acute Leukemia as Secondary Diagnosis with CC or High Dose Chemotherapy AgentRW 2.1585
- 839Chemotherapy with Acute Leukemia as Secondary Diagnosis without CC/MCCRW 1.3782
MDC 17 · Myeloproliferative Diseases and Disorders, Poorly Differentiated Neoplasms
ICD-9-CM equivalent
Converter →- 205.02Acute myeloid leukemia, in relapseapproximate
From the CMS 2018 General Equivalence Mappings (GEMs), the final GEMs release.
Code history
- 2016
- 2017
- 2018
- 2019
- 2020
- 2021
- 2022
- 2023
- 2024
- 2025
- 2026
- 2027
- FY2016 (effective 10/1/2015): Added (first year of ICD-10-CM)
- No changes since FY2016.
Common questions about C92.42
Is C92.42 billable?
- Yes. C92.42 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can C92.42 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict C92.42 as a principal diagnosis.
Is C92.42 a CC or MCC?
- C92.42 is a CC (complication or comorbidity) under MS-DRG v44.0, unless excluded by the principal diagnosis.
What DRG does C92.42 group to?
- C92.42 is used in the MS-DRG v44.0 logic for MS-DRG 820 (Lymphoma and Leukemia with Major O.R. Procedures with MCC), MS-DRG 821 (Lymphoma and Leukemia with Major O.R. Procedures with CC), MS-DRG 822 (Lymphoma and Leukemia with Major O.R. Procedures without CC/MCC), MS-DRG 834 (Acute Leukemia with MCC), MS-DRG 835 (Acute Leukemia with CC), MS-DRG 836 (Acute Leukemia without CC/MCC) and 4 more. Which one applies depends on whether it is the principal diagnosis and on the rest of the claim.
What is the ICD-9 code for C92.42?
- The CMS General Equivalence Mappings map C92.42 to ICD-9-CM 205.02.