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ICD-10-CM 2027 diagnosis code

E08.321Diabetes mellitus due to underlying condition with mild nonproliferative diabetic retinopathy with macular edema

Not billable — use a more specific codeRequires 7th character

E08.321 is a header code, so it can't be reported by itself. Choose one of the 4 more specific codes beneath it and add the required 7th character.Short description: Diab d/t undrl cond w mild nonprlf diab rtnop w mclr edema

Code last changed in FY2017 (effective October 1, 2016). Source: official FY2027 ICD-10-CM release from CDC/NCHS and CMS. Page updated September 29, 2026. About our data

About E08.321

E08.321 is the ICD-10-CM diagnosis code for diabetes mellitus due to underlying condition with mild nonproliferative diabetic retinopathy with macular edema. It belongs to category E08 (diabetes mellitus due to underlying condition), block E08-E13 (diabetes mellitus) and chapter 4 (endocrine, nutritional and metabolic diseases). It is a header code, so it can't be reported by itself; one of its 4 subcodes must be used instead.

Within E08.32 (diabetes mellitus due to underlying condition with mild nonproliferative diabetic retinopathy), E08.321 is specifically for diabetes mellitus due to underlying condition with mild nonproliferative diabetic retinopathy with macular edema. Related codes cover without macular edema (E08.329).

Codes in this range require a 7th character: 1 for right eye, 2 for left eye, 3 for bilateral and 9 for unspecified eye. Use placeholder "X" characters to fill any empty positions before the 7th character.

Code first the underlying condition, such as: congenital rubella (P35.0), Cushing's syndrome (E24.-), cystic fibrosis (E84.-), malignant neoplasm (C00-C96) and 2 more.

Use an additional code to identify control using: injectable non-insulin antidiabetic drugs (Z79.85), insulin (Z79.4), oral antidiabetic drugs (Z79.84) and oral hypoglycemic drugs (Z79.84).

It has been part of ICD-10-CM since the code set took effect on October 1, 2015, and changed in FY2017 (expanded into subcodes).

7th character

One of the following 7th characters is to be assigned to codes in subcategory E08.32 to designate laterality of the disease:

Notes that apply from higher levels

Instructions written at a parent level also apply to E08.321.

› From E08 Diabetes mellitus due to underlying condition
Excludes1
  • drug or chemical induced diabetes mellitus (E09.-)
  • gestational diabetes (O24.4-)
  • neonatal diabetes mellitus (P70.2)
  • postpancreatectomy diabetes mellitus (E13.-)
  • postprocedural diabetes mellitus (E13.-)
  • secondary diabetes mellitus NEC (E13.-)
  • type 1 diabetes mellitus (E10.-)
  • type 2 diabetes mellitus (E11.-)
Code first
  • the underlying condition, such as:
  • congenital rubella (P35.0)
  • Cushing's syndrome (E24.-)
  • cystic fibrosis (E84.-)
  • malignant neoplasm (C00-C96)
  • malnutrition (E40-E46)
  • pancreatitis and other diseases of the pancreas (K85-K86.-)
Use additional code
  • code to identify control using:
  • injectable non-insulin antidiabetic drugs (Z79.85)
  • insulin (Z79.4)
  • oral antidiabetic drugs (Z79.84)
  • oral hypoglycemic drugs (Z79.84)

Broader instructions also apply from Chapter 4: Endocrine, nutritional and metabolic diseases.

Alphabetic index entries

2 entries

Terms in the official ICD-10-CM index that lead to E08.321.

Code history

  1. 2016
  2. 2017
  3. 2018
  4. 2019
  5. 2020
  6. 2021
  7. 2022
  8. 2023
  9. 2024
  10. 2025
  11. 2026
  12. 2027
  • FY2016 (effective 10/1/2015): Added (first year of ICD-10-CM)
  • FY2017 (effective 10/1/2016): Expanded — no longer billable

Common questions about E08.321

Is E08.321 billable?

No. E08.321 is a header code. Report one of its more specific subcodes instead.