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ICD-10-CM 2027 diagnosis code

E08.3591Diabetes mellitus due to underlying condition with proliferative diabetic retinopathy without macular edema, right eye

✓ Billable / specificRequires 7th characterManifestation — not principal

E08.3591 is a valid, billable ICD-10-CM code for diabetes mellitus due to underlying condition with proliferative diabetic retinopathy without macular edema, right eye. It can be reported on claims for dates of service from October 1, 2026 – September 30, 2027.Short description: Diab with prolif diabetic rtnop without macular edema, r eye

Code last changed in FY2017 (effective October 1, 2016). Source: official FY2027 ICD-10-CM release from CDC/NCHS and CMS. Page updated September 29, 2026. About our data

About E08.3591

E08.3591 is the ICD-10-CM diagnosis code for diabetes mellitus due to underlying condition with proliferative diabetic retinopathy without macular edema, right eye. It belongs to category E08 (diabetes mellitus due to underlying condition), block E08-E13 (diabetes mellitus) and chapter 4 (endocrine, nutritional and metabolic diseases). It is billable, so it can be reported on its own for dates of service from October 1, 2026 through September 30, 2027.

The 7th character "1" means right eye.

Code first the underlying condition, such as: congenital rubella (P35.0), Cushing's syndrome (E24.-), cystic fibrosis (E84.-), malignant neoplasm (C00-C96) and 2 more.

Use an additional code to identify control using: injectable non-insulin antidiabetic drugs (Z79.85), insulin (Z79.4), oral antidiabetic drugs (Z79.84) and oral hypoglycemic drugs (Z79.84).

It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.

In MS-DRG v44.0, it is part of the grouping logic for DRG 008 (Simultaneous Pancreas, Islet Cell and Kidney Transplant, relative weight 5.5146), DRG 010 (Pancreas or Islet Cell Transplant, relative weight 7.5259), DRG 019 (Simultaneous Pancreas, Islet Cell and Kidney Transplant with Hemodialysis, relative weight 7.5493), DRG 124 (Other Disorders of the Eye with MCC or Thrombolytic Agent, relative weight 1.2471) and DRG 125 (Other Disorders of the Eye without MCC, relative weight 0.7702), in Pre-MDC and MDC 02 (Diseases and Disorders of the Eye), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.

It is a manifestation code, so it describes the effect of an underlying disease and can't be the principal diagnosis. Code the underlying condition first.

It was added in FY2017, effective October 1, 2016.

Before ICD-10, this condition was coded in ICD-9-CM as 249.50 (secondary diabetes mellitus with ophthalmic manifestations, not stated as uncontrolled, or unspecified) and 362.02 (proliferative diabetic retinopathy).

7th character

1right eye

Other encounter types for E08.359:

Notes that apply from higher levels

Instructions written at a parent level also apply to E08.3591.

› From E08 Diabetes mellitus due to underlying condition
Excludes1
  • drug or chemical induced diabetes mellitus (E09.-)
  • gestational diabetes (O24.4-)
  • neonatal diabetes mellitus (P70.2)
  • postpancreatectomy diabetes mellitus (E13.-)
  • postprocedural diabetes mellitus (E13.-)
  • secondary diabetes mellitus NEC (E13.-)
  • type 1 diabetes mellitus (E10.-)
  • type 2 diabetes mellitus (E11.-)
Code first
  • the underlying condition, such as:
  • congenital rubella (P35.0)
  • Cushing's syndrome (E24.-)
  • cystic fibrosis (E84.-)
  • malignant neoplasm (C00-C96)
  • malnutrition (E40-E46)
  • pancreatitis and other diseases of the pancreas (K85-K86.-)
Use additional code
  • code to identify control using:
  • injectable non-insulin antidiabetic drugs (Z79.85)
  • insulin (Z79.4)
  • oral antidiabetic drugs (Z79.84)
  • oral hypoglycemic drugs (Z79.84)

Broader instructions also apply from Chapter 4: Endocrine, nutritional and metabolic diseases.

MS-DRG v44.0 grouping

All DRGs →

Inpatient MS-DRGs this diagnosis can group to, as the principal or a secondary diagnosis, depending on the rest of the claim.

ICD-9-CM equivalent

Converter →
  • 249.50Secondary diabetes mellitus with ophthalmic manifestations, not stated as uncontrolled, or unspecifiedapproximate, combination
  • 362.02Proliferative diabetic retinopathyapproximate, combination

From the CMS 2018 General Equivalence Mappings (GEMs), the final GEMs release.

Code history

  1. 2016
  2. 2017
  3. 2018
  4. 2019
  5. 2020
  6. 2021
  7. 2022
  8. 2023
  9. 2024
  10. 2025
  11. 2026
  12. 2027
  • FY2017 (effective 10/1/2016): Added
  • No changes since FY2017.

Common questions about E08.3591

Is E08.3591 billable?

Yes. E08.3591 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).

What does the "1" at the end of E08.3591 mean?

It is the 7th character for right eye.

Can E08.3591 be used as a principal diagnosis?

No. It is a manifestation code, so it describes the effect of an underlying disease and can't be the principal diagnosis. Code the underlying condition first.

Is E08.3591 a CC or MCC?

No. E08.3591 is neither a CC nor an MCC under MS-DRG v44.0.

What DRG does E08.3591 group to?

E08.3591 is used in the MS-DRG v44.0 logic for MS-DRG 008 (Simultaneous Pancreas, Islet Cell and Kidney Transplant), MS-DRG 010 (Pancreas or Islet Cell Transplant), MS-DRG 019 (Simultaneous Pancreas, Islet Cell and Kidney Transplant with Hemodialysis), MS-DRG 124 (Other Disorders of the Eye with MCC or Thrombolytic Agent) and MS-DRG 125 (Other Disorders of the Eye without MCC). Which one applies depends on whether it is the principal diagnosis and on the rest of the claim.

What is the ICD-9 code for E08.3591?

The CMS General Equivalence Mappings map E08.3591 to ICD-9-CM 249.50 and 362.02.