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ICD-10-CM 2027 diagnosis code

E35Disorders of endocrine glands in diseases classified elsewhere

✓ Billable / specificManifestation — not principal

E35 is a valid, billable ICD-10-CM code for disorders of endocrine glands in diseases classified elsewhere. It can be reported on claims for dates of service from October 1, 2026 – September 30, 2027.Short description: Disorders of endocrine glands in diseases classd elswhr

Code unchanged since ICD-10-CM took effect on October 1, 2015. Source: official FY2027 ICD-10-CM release from CDC/NCHS and CMS. Page updated September 29, 2026. About our data

About E35

E35 is the ICD-10-CM diagnosis code for disorders of endocrine glands in diseases classified elsewhere. It belongs to block E20-E35 (disorders of other endocrine glands) and chapter 4 (endocrine, nutritional and metabolic diseases). It is billable, so it can be reported on its own for dates of service from October 1, 2026 through September 30, 2027.

Don't report E35 together with the conditions in its Excludes1 note: Echinococcus granulosus infection of thyroid gland (B67.3), meningococcal hemorrhagic adrenalitis (A39.1), syphilis of endocrine gland (A52.79), tuberculosis of adrenal gland, except calcification (A18.7) and 3 more.

Code first underlying disease, such as: late congenital syphilis of thymus gland [Dubois disease] (A50.59).

It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.

In MS-DRG v44.0, it is part of the grouping logic for DRG 011 (Tracheostomy for Face, Mouth and Neck Diagnoses or Laryngectomy with MCC, relative weight 5.6154), DRG 012 (Tracheostomy for Face, Mouth and Neck Diagnoses or Laryngectomy with CC, relative weight 4.381), DRG 013 (Tracheostomy for Face, Mouth and Neck Diagnoses or Laryngectomy without CC/MCC, relative weight 2.7307), DRG 643 (Endocrine Disorders with MCC, relative weight 1.6139), DRG 644 (Endocrine Disorders with CC, relative weight 1.0044) and DRG 645 (Endocrine Disorders without CC/MCC, relative weight 0.7459), in Pre-MDC and MDC 10 (Endocrine, Nutritional and Metabolic Diseases and Disorders), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.

It is a manifestation code, so it describes the effect of an underlying disease and can't be the principal diagnosis. Code the underlying condition first.

It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.

Before ICD-10, this condition was coded in ICD-9-CM as 246.8 (other specified disorders of thyroid), 255.8 (other specified disorders of adrenal glands) and 259.8 (other specified endocrine disorders).

Coding notes

Excludes1Not coded here — never report together with this code
  • Echinococcus granulosus infection of thyroid gland (B67.3)
  • meningococcal hemorrhagic adrenalitis (A39.1)
  • syphilis of endocrine gland (A52.79)
  • tuberculosis of adrenal gland, except calcification (A18.7)
  • tuberculosis of endocrine gland NEC (A18.82)
  • tuberculosis of thyroid gland (A18.81)
  • Waterhouse-Friderichsen syndrome (A39.1)
Code firstSequence the underlying condition first
  • underlying disease, such as:
  • late congenital syphilis of thymus gland [Dubois disease] (A50.59)

Notes that apply from higher levels

Instructions written at a parent level also apply to E35.

Broader instructions also apply from E20-E35 Disorders of other endocrine glands and Chapter 4: Endocrine, nutritional and metabolic diseases.

MS-DRG v44.0 grouping

All DRGs →

Inpatient MS-DRGs this diagnosis can group to, as the principal or a secondary diagnosis, depending on the rest of the claim.

ICD-9-CM equivalent

Converter →
  • 246.8Other specified disorders of thyroidapproximate
  • 255.8Other specified disorders of adrenal glandsapproximate
  • 259.8Other specified endocrine disordersapproximate

From the CMS 2018 General Equivalence Mappings (GEMs), the final GEMs release.

Code history

  1. 2016
  2. 2017
  3. 2018
  4. 2019
  5. 2020
  6. 2021
  7. 2022
  8. 2023
  9. 2024
  10. 2025
  11. 2026
  12. 2027
  • FY2016 (effective 10/1/2015): Added (first year of ICD-10-CM)
  • No changes since FY2016.

Common questions about E35

Is E35 billable?

Yes. E35 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).

Can E35 be used as a principal diagnosis?

No. It is a manifestation code, so it describes the effect of an underlying disease and can't be the principal diagnosis. Code the underlying condition first.

Is E35 a CC or MCC?

No. E35 is neither a CC nor an MCC under MS-DRG v44.0.

What DRG does E35 group to?

E35 is used in the MS-DRG v44.0 logic for MS-DRG 011 (Tracheostomy for Face, Mouth and Neck Diagnoses or Laryngectomy with MCC), MS-DRG 012 (Tracheostomy for Face, Mouth and Neck Diagnoses or Laryngectomy with CC), MS-DRG 013 (Tracheostomy for Face, Mouth and Neck Diagnoses or Laryngectomy without CC/MCC), MS-DRG 643 (Endocrine Disorders with MCC), MS-DRG 644 (Endocrine Disorders with CC) and MS-DRG 645 (Endocrine Disorders without CC/MCC). Which one applies depends on whether it is the principal diagnosis and on the rest of the claim.

What is the ICD-9 code for E35?

The CMS General Equivalence Mappings map E35 to ICD-9-CM 246.8, 255.8 and 259.8.