F11.281Opioid dependence with opioid-induced sexual dysfunction

F11.281 is the ICD-10-CM diagnosis code for opioid dependence with opioid-induced sexual dysfunction. It belongs to category F11 (opioid related disorders), block F10-F19 (mental and behavioral disorders due to psychoactive substance use) and chapter 5 (mental, Behavioral and Neurodevelopmental disorders). It is billable, so it can be reported on its own for dates of service from October 1, 2026 through September 30, 2027.

Within F11.28 (opioid dependence with other opioid-induced disorder), F11.281 is specifically for opioid dependence with opioid-induced sexual dysfunction. Related codes cover opioid-induced sleep disorder (F11.282) and other opioid-induced disorder (F11.288).

As a secondary diagnosis it is a CC (complication or comorbidity), which can move an inpatient stay into the "with CC" MS-DRG of its family, unless the principal diagnosis excludes it.

In MS-DRG v44.0, it is part of the grouping logic for DRG 894 (Alcohol, Drug Abuse or Dependence, Left AMA, relative weight 0.6275), DRG 895 (Alcohol, Drug Abuse or Dependence with Rehabilitation Therapy, relative weight 1.4266), DRG 896 (Alcohol, Drug Abuse or Dependence without Rehabilitation Therapy with MCC, relative weight 1.6617) and DRG 897 (Alcohol, Drug Abuse or Dependence without Rehabilitation Therapy without MCC, relative weight 0.8584), in MDC 20 (Alcohol/Drug Use and Alcohol/Drug Induced Organic Mental Disorders), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.

It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.

Before ICD-10, this condition was coded in ICD-9-CM as 292.89 (other specified drug-induced mental disorders) and 304.00 (opioid type dependence, unspecified).