ICD-10-CM 2027 diagnosis code
F48.1Depersonalization-derealization syndrome
F48.1 is a valid, billable ICD-10-CM code for depersonalization-derealization syndrome. It can be reported on claims for dates of service from October 1, 2026 – September 30, 2027.
Looking up by condition? See ICD-10 code for Derealization, ICD-10 code for Depersonalization.
Code unchanged since ICD-10-CM took effect on October 1, 2015. Source: official FY2027 ICD-10-CM release from CDC/NCHS and CMS. Page updated September 29, 2026. About our data
About F48.1
F48.1 is the ICD-10-CM diagnosis code for Depersonalization-derealization syndrome. It belongs to category F48 (other nonpsychotic mental disorders), block F40-F48 (anxiety, dissociative, stress-related, somatoform and other nonpsychotic mental disorders) and chapter 5 (mental, Behavioral and Neurodevelopmental disorders). It is billable, so it can be reported on its own for dates of service from October 1, 2026 through September 30, 2027.
Within F48 (other nonpsychotic mental disorders), F48.1 is specifically for Depersonalization-derealization syndrome. Related codes cover Pseudobulbar affect (F48.2), other specified nonpsychotic mental disorders (F48.8) and nonpsychotic mental disorder, unspecified (F48.9).
It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.
In MS-DRG v44.0, it is part of the grouping logic for DRG 882 (Neuroses Except Depressive, relative weight 0.9952), in MDC 19 (Mental Diseases and Disorders), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.
It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.
Before ICD-10, this condition was coded in ICD-9-CM as 300.6 (Depersonalization disorder).
Notes that apply from higher levels
Instructions written at a parent level also apply to F48.1.
Broader instructions also apply from Chapter 5: Mental, Behavioral and Neurodevelopmental disorders.
Alphabetic index entries
10 entriesTerms in the official ICD-10-CM index that lead to F48.1.
- Depersonalization (in neurotic state) (neurotic) (syndrome)
- Derealization (neurotic)
- Disorder (of) › depersonalization
- Episode › depersonalization (in neurotic state)
- Neurosis, neurotic › depersonalization
- Neurosis, neurotic › state › with depersonalization episode
- Psychoneurosis, psychoneurotic › depersonalization
- Reaction › psychoneurotic › depersonalization
- State (of) › neurotic › with depersonalization
- Syndrome › depersonalization (-derealization)
MS-DRG v44.0 grouping
All DRGs →Inpatient MS-DRGs this diagnosis can group to, as the principal or a secondary diagnosis, depending on the rest of the claim.
MDC 19 · Mental Diseases and Disorders
ICD-9-CM equivalent
Converter →- 300.6Depersonalization disorderexact
From the CMS 2018 General Equivalence Mappings (GEMs), the final GEMs release.
Code history
- 2016
- 2017
- 2018
- 2019
- 2020
- 2021
- 2022
- 2023
- 2024
- 2025
- 2026
- 2027
- FY2016 (effective 10/1/2015): Added (first year of ICD-10-CM)
- No changes since FY2016.
Common questions about F48.1
Is F48.1 billable?
- Yes. F48.1 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can F48.1 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict F48.1 as a principal diagnosis.
Is F48.1 a CC or MCC?
- No. F48.1 is neither a CC nor an MCC under MS-DRG v44.0.
What DRG does F48.1 group to?
- F48.1 is used in the MS-DRG v44.0 logic for MS-DRG 882 (Neuroses Except Depressive). Which one applies depends on whether it is the principal diagnosis and on the rest of the claim.
What is the ICD-9 code for F48.1?
- The CMS General Equivalence Mappings map F48.1 to ICD-9-CM 300.6.