F55.8Abuse of other non-psychoactive substances

F55.8 is the ICD-10-CM diagnosis code for abuse of other non-psychoactive substances. It belongs to category F55 (abuse of non-psychoactive substances), block F50-F59 (behavioral syndromes associated with physiological disturbances and physical factors) and chapter 5 (mental, Behavioral and Neurodevelopmental disorders). It is billable, so it can be reported on its own for dates of service from October 1, 2026 through September 30, 2027.

Within F55, choose F55.8 (other non-psychoactive substances) only when documentation doesn't support a more specific option: antacids (F55.0), herbal or folk remedies (F55.1), laxatives (F55.2), steroids or hormones (F55.3) and vitamins (F55.4).

It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.

In MS-DRG v44.0, it is part of the grouping logic for DRG 894 (Alcohol, Drug Abuse or Dependence, Left AMA, relative weight 0.6275), DRG 895 (Alcohol, Drug Abuse or Dependence with Rehabilitation Therapy, relative weight 1.4266), DRG 896 (Alcohol, Drug Abuse or Dependence without Rehabilitation Therapy with MCC, relative weight 1.6617) and DRG 897 (Alcohol, Drug Abuse or Dependence without Rehabilitation Therapy without MCC, relative weight 0.8584), in MDC 20 (Alcohol/Drug Use and Alcohol/Drug Induced Organic Mental Disorders), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.

It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.

Before ICD-10, this condition was coded in ICD-9-CM as 305.90 (other, mixed, or unspecified drug abuse, unspecified), 305.91 (other, mixed, or unspecified drug abuse, continuous), 305.92 (other, mixed, or unspecified drug abuse, episodic) and 1 more.