G12.25Progressive spinal muscle atrophy

G12.25 is the ICD-10-CM diagnosis code for progressive spinal muscle atrophy. It belongs to category G12 (spinal muscular atrophy and related syndromes), block G10-G14 (systemic atrophies primarily affecting the central nervous system) and chapter 6 (diseases of the nervous system). It is billable, so it can be reported on its own for dates of service from October 1, 2026 through September 30, 2027.

Within G12.2 (motor neuron disease), G12.25 is specifically for progressive spinal muscle atrophy. Related codes cover unspecified (G12.20), Amyotrophic lateral sclerosis (G12.21), progressive bulbar palsy (G12.22), primary lateral sclerosis (G12.23), familial motor neuron disease (G12.24) and other motor neuron disease (G12.29).

As a secondary diagnosis it is a CC (complication or comorbidity), which can move an inpatient stay into the "with CC" MS-DRG of its family, unless the principal diagnosis excludes it.

In MS-DRG v44.0, it is part of the grouping logic for DRG 056 (Degenerative Nervous System Disorders with MCC, relative weight 2.2655) and DRG 057 (Degenerative Nervous System Disorders without MCC, relative weight 1.2838), in MDC 01 (Diseases and Disorders of the Nervous System), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.

It was added in FY2018, effective October 1, 2017.

Before ICD-10, this condition was coded in ICD-9-CM as 335.10 (spinal muscular atrophy, unspecified).