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ICD-10-CM 2027 diagnosis code

I21Acute myocardial infarction

Not billable — use a more specific code

I21 is a header code, so it can't be reported by itself. Choose one of the 8 more specific codes beneath it.

Code last changed in FY2018 (effective October 1, 2017). Source: official FY2027 ICD-10-CM release from CDC/NCHS and CMS. Page updated September 29, 2026. About our data

About I21

I21 is the ICD-10-CM diagnosis code for acute myocardial infarction. It belongs to block I20-I25 (ischemic heart diseases) and chapter 9 (diseases of the circulatory system). It is a header code, so it can't be reported by itself; one of its 8 subcodes must be used instead.

To report this condition, pick the subcode that matches the documentation: I21.0 (wall), I21.1 (wall), I21.2 (sites), I21.3 (site), I21.4 (infarction), I21.9 (unspecified), I21.A (infarction) and I21.B (dysfunction).

The conditions in its Excludes2 note aren't part of I21, but may be coded alongside it if the patient has both: old myocardial infarction (I25.2), postmyocardial infarction syndrome (I24.1) and subsequent type 1 myocardial infarction (I22.-).

Use an additional code, if applicable, to identify: exposure to environmental tobacco smoke (Z77.22), history of tobacco dependence (Z87.891), occupational exposure to environmental tobacco smoke (Z57.31), status post administration of tPA (rtPA) in a different facility within the last 24 hours prior to admission to current facility (Z92.82), tobacco dependence (F17.-) and 1 more.

It has been part of ICD-10-CM since the code set took effect on October 1, 2015, and changed in FY2018 (title revised).

Specific codes under I21

Coding notes

IncludesFurther defines the content of the category
  • cardiac infarction
  • coronary (artery) embolism
  • coronary (artery) occlusion
  • coronary (artery) rupture
  • coronary (artery) thrombosis
  • infarction of heart, myocardium, or ventricle
  • myocardial infarction specified as acute or with a stated duration of 4 weeks (28 days) or less from onset
Excludes2Not included here — may be reported together if both conditions exist
  • old myocardial infarction (I25.2)
  • postmyocardial infarction syndrome (I24.1)
  • subsequent type 1 myocardial infarction (I22.-)
Use additional codeAdd a secondary code to fully describe the condition
  • code, if applicable, to identify:
  • exposure to environmental tobacco smoke (Z77.22)
  • history of tobacco dependence (Z87.891)
  • occupational exposure to environmental tobacco smoke (Z57.31)
  • status post administration of tPA (rtPA) in a different facility within the last 24 hours prior to admission to current facility (Z92.82)
  • tobacco dependence (F17.-)
  • tobacco use (Z72.0)

Notes that apply from higher levels

Instructions written at a parent level also apply to I21.

Codes whose notes reference I21

Code history

  1. 2016
  2. 2017
  3. 2018
  4. 2019
  5. 2020
  6. 2021
  7. 2022
  8. 2023
  9. 2024
  10. 2025
  11. 2026
  12. 2027
  • FY2016 (effective 10/1/2015): Added (first year of ICD-10-CM)
  • FY2018 (effective 10/1/2017): Title revised — was “ST elevation (STEMI) and non-ST elevation (NSTEMI) myocardial infarction”

Common questions about I21

Is I21 billable?

No. I21 is a header code. Report one of its more specific subcodes instead.