ICD-10-CM 2027 diagnosis code
I21Acute myocardial infarction
I21 is a header code, so it can't be reported by itself. Choose one of the 8 more specific codes beneath it.
Code last changed in FY2018 (effective October 1, 2017). Source: official FY2027 ICD-10-CM release from CDC/NCHS and CMS. Page updated September 29, 2026. About our data
About I21
I21 is the ICD-10-CM diagnosis code for acute myocardial infarction. It belongs to block I20-I25 (ischemic heart diseases) and chapter 9 (diseases of the circulatory system). It is a header code, so it can't be reported by itself; one of its 8 subcodes must be used instead.
To report this condition, pick the subcode that matches the documentation: I21.0 (wall), I21.1 (wall), I21.2 (sites), I21.3 (site), I21.4 (infarction), I21.9 (unspecified), I21.A (infarction) and I21.B (dysfunction).
The conditions in its Excludes2 note aren't part of I21, but may be coded alongside it if the patient has both: old myocardial infarction (I25.2), postmyocardial infarction syndrome (I24.1) and subsequent type 1 myocardial infarction (I22.-).
Use an additional code, if applicable, to identify: exposure to environmental tobacco smoke (Z77.22), history of tobacco dependence (Z87.891), occupational exposure to environmental tobacco smoke (Z57.31), status post administration of tPA (rtPA) in a different facility within the last 24 hours prior to admission to current facility (Z92.82), tobacco dependence (F17.-) and 1 more.
It has been part of ICD-10-CM since the code set took effect on October 1, 2015, and changed in FY2018 (title revised).
Specific codes under I21
- I21.0ST elevation (STEMI) myocardial infarction of anterior wall
- I21.01ST elevation (STEMI) myocardial infarction involving left main coronary arteryBillable
- I21.02ST elevation (STEMI) myocardial infarction involving left anterior descending coronary arteryBillable
- I21.09ST elevation (STEMI) myocardial infarction involving other coronary artery of anterior wallBillable
- I21.1ST elevation (STEMI) myocardial infarction of inferior wall
- I21.2ST elevation (STEMI) myocardial infarction of other sites
- I21.3ST elevation (STEMI) myocardial infarction of unspecified siteBillable
- I21.4Non-ST elevation (NSTEMI) myocardial infarctionBillable
- I21.9Acute myocardial infarction, unspecifiedBillable
- I21.AOther type of myocardial infarction
- I21.BMyocardial infarction with coronary microvascular dysfunctionBillable
Coding notes
- cardiac infarction
- coronary (artery) embolism
- coronary (artery) occlusion
- coronary (artery) rupture
- coronary (artery) thrombosis
- infarction of heart, myocardium, or ventricle
- myocardial infarction specified as acute or with a stated duration of 4 weeks (28 days) or less from onset
- code, if applicable, to identify:
- exposure to environmental tobacco smoke (Z77.22)
- history of tobacco dependence (Z87.891)
- occupational exposure to environmental tobacco smoke (Z57.31)
- status post administration of tPA (rtPA) in a different facility within the last 24 hours prior to admission to current facility (Z92.82)
- tobacco dependence (F17.-)
- tobacco use (Z72.0)
Notes that apply from higher levels
Instructions written at a parent level also apply to I21.
Broader instructions also apply from I20-I25 Ischemic heart diseases and Chapter 9: Diseases of the circulatory system.
Codes whose notes reference I21
Code history
- 2016
- 2017
- 2018
- 2019
- 2020
- 2021
- 2022
- 2023
- 2024
- 2025
- 2026
- 2027
- FY2016 (effective 10/1/2015): Added (first year of ICD-10-CM)
- FY2018 (effective 10/1/2017): Title revised — was “ST elevation (STEMI) and non-ST elevation (NSTEMI) myocardial infarction”
Common questions about I21
Is I21 billable?
- No. I21 is a header code. Report one of its more specific subcodes instead.