ICD-10-CM 2027 diagnosis code
K21.01Gastro-esophageal reflux disease with esophagitis, with bleeding
K21.01 is a valid, billable ICD-10-CM code for gastro-esophageal reflux disease with esophagitis, with bleeding. It can be reported on claims for dates of service from October 1, 2026 – September 30, 2027.Short description: Gastro-esophageal reflux dis with esophagitis, with bleed
Code last changed in FY2021 (effective October 1, 2020). Source: official FY2027 ICD-10-CM release from CDC/NCHS and CMS. Page updated September 29, 2026. About our data
About K21.01
K21.01 is the ICD-10-CM diagnosis code for Gastro-esophageal reflux disease with esophagitis, with bleeding. It belongs to category K21 (Gastro-esophageal reflux disease), block K20-K31 (diseases of esophagus, stomach and duodenum) and chapter 11 (diseases of the digestive system). It is billable, so it can be reported on its own for dates of service from October 1, 2026 through September 30, 2027.
Within K21.0 (Gastro-esophageal reflux disease with esophagitis), K21.01 is specifically for Gastro-esophageal reflux disease with esophagitis, with bleeding. Related codes cover without bleeding (K21.00).
As a secondary diagnosis it is an MCC (major complication or comorbidity), which can move an inpatient stay into the highest-paying "with MCC" MS-DRG of its family, unless the principal diagnosis excludes it.
In MS-DRG v44.0, it is part of the grouping logic for DRG 368 (Major Esophageal Disorders with MCC, relative weight 1.6433), DRG 369 (Major Esophageal Disorders with CC, relative weight 0.9922) and DRG 370 (Major Esophageal Disorders without CC/MCC, relative weight 0.6744), in MDC 06 (Diseases and Disorders of the Digestive System), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.
It was added in FY2021, effective October 1, 2020.
Notes that apply from higher levels
Instructions written at a parent level also apply to K21.01.
› From K21 Gastro-esophageal reflux disease
- newborn esophageal reflux (P78.83)
Broader instructions also apply from K20-K31 Diseases of esophagus, stomach and duodenum and Chapter 11: Diseases of the digestive system.
Alphabetic index entries
7 entriesTerms in the official ICD-10-CM index that lead to K21.01.
- Allergy, allergic (reaction) (to) › milk protein › gastroesophageal reflux › with esophagitis (without bleeding) › with bleeding
- Disease, diseased › gastroesophageal reflux (GERD) › with esophagitis (without bleeding) › with bleeding
- Esophagitis (acute) (alkaline) (chemical) (chronic) (infectional) (necrotic) (peptic) (postoperative) (without bleeding) › due to gastrointestinal reflux disease (without bleeding) › with bleeding
- Esophagitis (acute) (alkaline) (chemical) (chronic) (infectional) (necrotic) (peptic) (postoperative) (without bleeding) › reflux › with bleeding
- Reflux › esophageal › with esophagitis (without bleeding) › with bleeding
- Reflux › gastroesophageal › with esophagitis (without bleeding) › with bleeding
- Ulcer, ulcerated, ulcerating, ulceration, ulcerative › esophagus (peptic) › due to › gastrointestinal reflux disease (without bleeding) › with bleeding
MS-DRG v44.0 grouping
All DRGs →Inpatient MS-DRGs this diagnosis can group to, as the principal or a secondary diagnosis, depending on the rest of the claim.
MDC 06 · Diseases and Disorders of the Digestive System
Code history
- 2016
- 2017
- 2018
- 2019
- 2020
- 2021
- 2022
- 2023
- 2024
- 2025
- 2026
- 2027
- FY2021 (effective 10/1/2020): Added
- No changes since FY2021.
Common questions about K21.01
Is K21.01 billable?
- Yes. K21.01 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can K21.01 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict K21.01 as a principal diagnosis.
Is K21.01 a CC or MCC?
- K21.01 is an MCC (major complication or comorbidity) under MS-DRG v44.0, unless excluded by the principal diagnosis.
What DRG does K21.01 group to?
- K21.01 is used in the MS-DRG v44.0 logic for MS-DRG 368 (Major Esophageal Disorders with MCC), MS-DRG 369 (Major Esophageal Disorders with CC) and MS-DRG 370 (Major Esophageal Disorders without CC/MCC). Which one applies depends on whether it is the principal diagnosis and on the rest of the claim.