ICD-10-CM 2027 diagnosis code
M45Ankylosing spondylitis
M45 is a header code, so it can't be reported by itself. Choose one of the 11 more specific codes beneath it.
Code unchanged since ICD-10-CM took effect on October 1, 2015. Source: official FY2027 ICD-10-CM release from CDC/NCHS and CMS. Page updated September 29, 2026. About our data
About M45
M45 is the ICD-10-CM diagnosis code for ankylosing spondylitis. It belongs to block M45-M49 (spondylopathies) and chapter 13 (diseases of the musculoskeletal system and connective tissue). It is a header code, so it can't be reported by itself; one of its 11 subcodes must be used instead.
To report this condition, pick the subcode that matches the documentation: M45.0 (of multiple sites in spine), M45.1 (of occipito-atlanto-axial region), M45.2 (of cervical region), M45.3 (of cervicothoracic region), M45.4 (of thoracic region), M45.5 (of thoracolumbar region), M45.6 (lumbar region), M45.7 (of lumbosacral region) and 3 more.
Don't report M45 together with the conditions in its Excludes1 note: arthropathy in Reiter's disease (M02.3-) and juvenile (ankylosing) spondylitis (M08.1).
The conditions in its Excludes2 note aren't part of M45, but may be coded alongside it if the patient has both: Behçet's disease (M35.2).
It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.
Specific codes under M45
- M45.0Ankylosing spondylitis of multiple sites in spineBillable
- M45.1Ankylosing spondylitis of occipito-atlanto-axial regionBillable
- M45.2Ankylosing spondylitis of cervical regionBillable
- M45.3Ankylosing spondylitis of cervicothoracic regionBillable
- M45.4Ankylosing spondylitis of thoracic regionBillable
- M45.5Ankylosing spondylitis of thoracolumbar regionBillable
- M45.6Ankylosing spondylitis lumbar regionBillable
- M45.7Ankylosing spondylitis of lumbosacral regionBillable
- M45.8Ankylosing spondylitis sacral and sacrococcygeal regionBillable
- M45.9Ankylosing spondylitis of unspecified sites in spineBillable
- M45.ANon-radiographic axial spondyloarthritis
- M45.A0Non-radiographic axial spondyloarthritis of unspecified sites in spineBillable
- M45.A1Non-radiographic axial spondyloarthritis of occipito-atlanto-axial regionBillable
- M45.A2Non-radiographic axial spondyloarthritis of cervical regionBillable
- M45.A3Non-radiographic axial spondyloarthritis of cervicothoracic regionBillable
- M45.A4Non-radiographic axial spondyloarthritis of thoracic regionBillable
- M45.A5Non-radiographic axial spondyloarthritis of thoracolumbar regionBillable
- M45.A6Non-radiographic axial spondyloarthritis of lumbar regionBillable
- M45.A7Non-radiographic axial spondyloarthritis of lumbosacral regionBillable
- M45.A8Non-radiographic axial spondyloarthritis of sacral and sacrococcygeal regionBillable
- M45.ABNon-radiographic axial spondyloarthritis of multiple sites in spineBillable
Coding notes
- Rheumatoid arthritis of spine
- Behçet's disease (M35.2)
Notes that apply from higher levels
Instructions written at a parent level also apply to M45.
Broader instructions also apply from Chapter 13: Diseases of the musculoskeletal system and connective tissue.
Codes whose notes reference M45
Code history
- 2016
- 2017
- 2018
- 2019
- 2020
- 2021
- 2022
- 2023
- 2024
- 2025
- 2026
- 2027
- FY2016 (effective 10/1/2015): Added (first year of ICD-10-CM)
- No changes since FY2016.
Common questions about M45
Is M45 billable?
- No. M45 is a header code. Report one of its more specific subcodes instead.