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ICD-10-CM 2027 diagnosis code

O02.81Inappropriate change in quantitative human chorionic gonadotropin (hCG) in early pregnancy

✓ Billable / specificMaternity · age 9–64Female only

O02.81 is a valid, billable ICD-10-CM code for inappropriate change in quantitative human chorionic gonadotropin (hcg) in early pregnancy. It can be reported on claims for dates of service from October 1, 2026 – September 30, 2027.Short description: Inapprop chg quantitav hCG in early pregnancy

Code unchanged since ICD-10-CM took effect on October 1, 2015. Source: official FY2027 ICD-10-CM release from CDC/NCHS and CMS. Page updated September 29, 2026. About our data

About O02.81

O02.81 is the ICD-10-CM diagnosis code for inappropriate change in quantitative human chorionic gonadotropin (hCG) in early pregnancy. It belongs to category O02 (other abnormal products of conception), block O00-O08 (pregnancy with abortive outcome) and chapter 15 (pregnancy, childbirth and the puerperium). It is billable, so it can be reported on its own for dates of service from October 1, 2026 through September 30, 2027.

Within O02.8 (other specified abnormal products of conception), O02.81 is specifically for inappropriate change in quantitative human chorionic gonadotropin (hCG) in early pregnancy. Related codes cover other abnormal products of conception (O02.89).

Use an additional code from category O08 to identify any associated complication.

It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.

In MS-DRG v44.0, it is part of the grouping logic for DRG 817 (Other Antepartum Diagnoses with O.R. Procedures with MCC, relative weight 2.0534), DRG 818 (Other Antepartum Diagnoses with O.R. Procedures with CC, relative weight 1.2942), DRG 819 (Other Antepartum Diagnoses with O.R. Procedures without CC/MCC, relative weight 0.7739), DRG 831 (Other Antepartum Diagnoses without O.R. Procedures with MCC, relative weight 1.1558), DRG 832 (Other Antepartum Diagnoses without O.R. Procedures with CC, relative weight 0.7585) and DRG 833 (Other Antepartum Diagnoses without O.R. Procedures without CC/MCC, relative weight 0.5002), in MDC 14 (Pregnancy, Childbirth and the Puerperium), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.

The Medicare Code Editor treats this as a maternity diagnosis, expected only for patients age 9 through 64.

It is on the CMS list of diagnoses consistent only with female patients (the sex-conflict edit itself was retired in FY2025).

It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.

Before ICD-10, this condition was coded in ICD-9-CM as 631.0 (inappropriate change in quantitative human chorionic gonadotropin (hCG) in early pregnancy).

Coding notes

Applicable toConditions and synonyms classified to this code
  • Biochemical pregnancy
  • Chemical pregnancy
  • Inappropriate level of quantitative human chorionic gonadotropin (hCG) for gestational age in early pregnancy

Notes that apply from higher levels

Instructions written at a parent level also apply to O02.81.

› From O02.8 Other specified abnormal products of conception
Excludes1
  • abnormal products of conception with blighted ovum (O02.0)
  • abnormal products of conception with hydatidiform mole (O01.-)
  • abnormal products of conception with nonhydatidiform mole (O02.0)
› From O02 Other abnormal products of conception
Excludes1
Use additional code
  • code from category O08 to identify any associated complication.

Broader instructions also apply from O00-O08 Pregnancy with abortive outcome and Chapter 15: Pregnancy, childbirth and the puerperium.

Alphabetic index entries

4 entries

Terms in the official ICD-10-CM index that lead to O02.81.

MS-DRG v44.0 grouping

All DRGs →

Inpatient MS-DRGs this diagnosis can group to, as the principal or a secondary diagnosis, depending on the rest of the claim.

ICD-9-CM equivalent

Converter →
  • 631.0Inappropriate change in quantitative human chorionic gonadotropin (hCG) in early pregnancyexact

From the CMS 2018 General Equivalence Mappings (GEMs), the final GEMs release.

Code history

  1. 2016
  2. 2017
  3. 2018
  4. 2019
  5. 2020
  6. 2021
  7. 2022
  8. 2023
  9. 2024
  10. 2025
  11. 2026
  12. 2027
  • FY2016 (effective 10/1/2015): Added (first year of ICD-10-CM)
  • No changes since FY2016.

Common questions about O02.81

Is O02.81 billable?

Yes. O02.81 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).

Can O02.81 be used as a principal diagnosis?

Yes. The Medicare Code Editor doesn't restrict O02.81 as a principal diagnosis.

Is O02.81 a CC or MCC?

No. O02.81 is neither a CC nor an MCC under MS-DRG v44.0.

What DRG does O02.81 group to?

O02.81 is used in the MS-DRG v44.0 logic for MS-DRG 817 (Other Antepartum Diagnoses with O.R. Procedures with MCC), MS-DRG 818 (Other Antepartum Diagnoses with O.R. Procedures with CC), MS-DRG 819 (Other Antepartum Diagnoses with O.R. Procedures without CC/MCC), MS-DRG 831 (Other Antepartum Diagnoses without O.R. Procedures with MCC), MS-DRG 832 (Other Antepartum Diagnoses without O.R. Procedures with CC) and MS-DRG 833 (Other Antepartum Diagnoses without O.R. Procedures without CC/MCC). Which one applies depends on whether it is the principal diagnosis and on the rest of the claim.

What is the ICD-9 code for O02.81?

The CMS General Equivalence Mappings map O02.81 to ICD-9-CM 631.0.