P57.0Kernicterus due to isoimmunization

P57.0 is the ICD-10-CM diagnosis code for kernicterus due to isoimmunization. It belongs to category P57 (kernicterus), block P50-P61 (hemorrhagic and hematological disorders of newborn) and chapter 16 (certain conditions originating in the perinatal period). It is billable, so it can be reported on its own for dates of service from October 1, 2026 through September 30, 2027.

Within P57 (kernicterus), P57.0 is specifically for kernicterus due to isoimmunization. Related codes cover other specified kernicterus (P57.8) and unspecified (P57.9).

As a secondary diagnosis it is an MCC (major complication or comorbidity), which can move an inpatient stay into the highest-paying "with MCC" MS-DRG of its family, unless the principal diagnosis excludes it.

In MS-DRG v44.0, it is part of the grouping logic for DRG 791 (Prematurity with Major Problems, relative weight 4.1075) and DRG 793 (Full Term Neonate with Major Problems, relative weight 4.2195), in MDC 15 (Newborns and Other Neonates with Conditions Originating in the Perinatal Period), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.

It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.

Before ICD-10, this condition was coded in ICD-9-CM as 773.4 (kernicterus of fetus or newborn due to isoimmunization).