S38.221AComplete traumatic amputation of penis, initial encounter

S38.221A is the ICD-10-CM diagnosis code for complete traumatic amputation of penis, initial encounter. It belongs to category S38 (crushing injury and traumatic amputation of abdomen, lower back, pelvis and external genitals), block S30-S39 (injuries to the abdomen, lower back, lumbar spine, pelvis and external genitals) and chapter 19 (injury, poisoning and certain other consequences of external causes). It is billable, so it can be reported on its own for dates of service from October 1, 2026 through September 30, 2027.

The 7th character "A" means initial encounter: use it while the patient is receiving active treatment for the condition.

It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.

In MS-DRG v44.0, it is part of the grouping logic for DRG 729 (Other Male Reproductive System Diagnoses with CC/MCC, relative weight 1.0544), DRG 730 (Other Male Reproductive System Diagnoses without CC/MCC, relative weight 0.6597), DRG 963 (Other Multiple Significant Trauma with MCC, relative weight 2.6363), DRG 964 (Other Multiple Significant Trauma with CC, relative weight 1.4972) and DRG 965 (Other Multiple Significant Trauma without CC/MCC, relative weight 1.0059), in MDC 12 (Diseases and Disorders of the Male Reproductive System) and MDC 24 (Multiple Significant Trauma), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.

It is on the CMS list of diagnoses consistent only with male patients (the sex-conflict edit itself was retired in FY2025).

It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.

Before ICD-10, this condition was coded in ICD-9-CM as 878.0 (open wound of penis, without mention of complication).