ICD-10-CM 2027 diagnosis code
T80.22XAAcute infection following transfusion, infusion, or injection of blood and blood products, initial encounter
T80.22XA is a valid, billable ICD-10-CM code for acute infection following transfusion, infusion, or injection of blood and blood products, initial encounter. It can be reported on claims for dates of service from October 1, 2026 – September 30, 2027.Short description: Acute infct fol tranfs,infusn,inject blood/products, init
Code unchanged since ICD-10-CM took effect on October 1, 2015. Source: official FY2027 ICD-10-CM release from CDC/NCHS and CMS. Page updated September 29, 2026. About our data
About T80.22XA
T80.22XA is the ICD-10-CM diagnosis code for acute infection following transfusion, infusion, or injection of blood and blood products, initial encounter. It belongs to category T80 (complications following infusion, transfusion and therapeutic injection), block T80-T88 (complications of surgical and medical care, not elsewhere classified) and chapter 19 (injury, poisoning and certain other consequences of external causes). It is billable, so it can be reported on its own for dates of service from October 1, 2026 through September 30, 2027.
The 7th character "A" means initial encounter: use it while the patient is receiving active treatment for the condition.
As a secondary diagnosis it is a CC (complication or comorbidity), which can move an inpatient stay into the "with CC" MS-DRG of its family, unless the principal diagnosis excludes it.
In MS-DRG v44.0, it is part of the grouping logic for DRG 791 (Prematurity with Major Problems, relative weight 4.1075), DRG 793 (Full Term Neonate with Major Problems, relative weight 4.2195), DRG 856 (Postoperative or Post-Traumatic Infections with O.R. Procedures with MCC, relative weight 4.4826), DRG 857 (Postoperative or Post-Traumatic Infections with O.R. Procedures with CC, relative weight 2.1678), DRG 858 (Postoperative or Post-Traumatic Infections with O.R. Procedures without CC/MCC, relative weight 1.4036), DRG 867 (Other Infectious and Parasitic Diseases Diagnoses with MCC, relative weight 2.1859) and 2 more, in MDC 15 (Newborns and Other Neonates with Conditions Originating in the Perinatal Period) and MDC 18 (Infectious and Parasitic Diseases, Systemic or Unspecified Sites), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.
It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.
Before ICD-10, this condition was coded in ICD-9-CM as 999.34 (acute infection following transfusion, infusion, or injection of blood and blood products).
7th character
Ainitial encounter
CC/MCC status for this injury by encounter: CC for A; Neither CC nor MCC for D, S.
Other encounter types for T80.22:
Notes that apply from higher levels
Instructions written at a parent level also apply to T80.22XA.
› From T80 Complications following infusion, transfusion and therapeutic injection
- complications following perfusion
- bone marrow transplant rejection (T86.01)
- febrile nonhemolytic transfusion reaction (R50.84)
- fluid overload due to transfusion (E87.71)
- posttransfusion purpura (D69.51)
- transfusion associated circulatory overload (TACO) (E87.71)
- transfusion (red blood cell) associated hemochromatosis (E83.111)
- transfusion related acute lung injury (TRALI) (J95.84)
Broader instructions also apply from T80-T88 Complications of surgical and medical care, not elsewhere classified and Chapter 19: Injury, poisoning and certain other consequences of external causes.
MS-DRG v44.0 grouping
All DRGs →Inpatient MS-DRGs this diagnosis can group to, as the principal or a secondary diagnosis, depending on the rest of the claim.
MDC 15 · Newborns and Other Neonates with Conditions Originating in the Perinatal Period
MDC 15 · Newborns and Other Neonates with Conditions Originating in the Perinatal Period
MDC 18 · Infectious and Parasitic Diseases, Systemic or Unspecified Sites
MDC 18 · Infectious and Parasitic Diseases, Systemic or Unspecified Sites
ICD-9-CM equivalent
Converter →- 999.34Acute infection following transfusion, infusion, or injection of blood and blood productsapproximate
From the CMS 2018 General Equivalence Mappings (GEMs), the final GEMs release.
Code history
- 2016
- 2017
- 2018
- 2019
- 2020
- 2021
- 2022
- 2023
- 2024
- 2025
- 2026
- 2027
- FY2016 (effective 10/1/2015): Added (first year of ICD-10-CM)
- No changes since FY2016.
Common questions about T80.22XA
Is T80.22XA billable?
- Yes. T80.22XA is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
What does the "A" at the end of T80.22XA mean?
- It is the 7th character for initial encounter. Per the official guidelines, use it while the patient is receiving active treatment for the condition.
Can T80.22XA be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict T80.22XA as a principal diagnosis.
Is T80.22XA a CC or MCC?
- T80.22XA is a CC (complication or comorbidity) under MS-DRG v44.0, unless excluded by the principal diagnosis.
What DRG does T80.22XA group to?
- T80.22XA is used in the MS-DRG v44.0 logic for MS-DRG 791 (Prematurity with Major Problems), MS-DRG 793 (Full Term Neonate with Major Problems), MS-DRG 856 (Postoperative or Post-Traumatic Infections with O.R. Procedures with MCC), MS-DRG 857 (Postoperative or Post-Traumatic Infections with O.R. Procedures with CC), MS-DRG 858 (Postoperative or Post-Traumatic Infections with O.R. Procedures without CC/MCC), MS-DRG 867 (Other Infectious and Parasitic Diseases Diagnoses with MCC) and 2 more. Which one applies depends on whether it is the principal diagnosis and on the rest of the claim.
What is the ICD-9 code for T80.22XA?
- The CMS General Equivalence Mappings map T80.22XA to ICD-9-CM 999.34.