Z00.6Encounter for examination for normal comparison and control in clinical research program

Z00.6 is the ICD-10-CM diagnosis code for encounter for examination for normal comparison and control in clinical research program. It belongs to category Z00 (encounter for general examination without complaint, suspected or reported diagnosis), block Z00-Z13 (persons encountering health services for examinations) and chapter 21 (factors influencing health status and contact with health services). It is billable, so it can be reported on its own for dates of service from October 1, 2026 through September 30, 2027.

Within Z00 (encounter for general examination without complaint, suspected or reported diagnosis), Z00.6 is specifically for encounter for examination for normal comparison and control in clinical research program. Related codes cover general adult medical examination (Z00.0), newborn, infant and child health examinations (Z00.1), examination for period of rapid growth in childhood (Z00.2), examination for adolescent development state (Z00.3), examination of potential donor of organ and tissue (Z00.5), examination for period of delayed growth in childhood (Z00.7) and other general examination (Z00.8).

It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.

In MS-DRG v44.0, it is part of the grouping logic for DRG 951 (Other Factors Influencing Health Status, relative weight 0.5577), in MDC 23 (Factors Influencing Health Status and Other Contacts with Health Services), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.

It is exempt from present-on-admission (POA) reporting, so no POA indicator is required.

It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.

Before ICD-10, this condition was coded in ICD-9-CM as V70.7 (examination of participant in clinical trial).