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ICD-10-CM 2027 diagnosis code

Z16.34Resistance to antimycobacterial drug(s)

Not billable — use a more specific code

Z16.34 is a header code, so it can't be reported by itself. Choose one of the 2 more specific codes beneath it.

Code unchanged since ICD-10-CM took effect on October 1, 2015. Source: official FY2027 ICD-10-CM release from CDC/NCHS and CMS. Page updated September 29, 2026. About our data

About Z16.34

Z16.34 is the ICD-10-CM diagnosis code for resistance to antimycobacterial drug(s). It belongs to category Z16 (resistance to antimicrobial drugs), block Z16 (resistance to antimicrobial drugs) and chapter 21 (factors influencing health status and contact with health services). It is a header code, so it can't be reported by itself; one of its 2 subcodes must be used instead.

Within Z16.3 (resistance to other antimicrobial drugs), Z16.34 is specifically for resistance to antimycobacterial drug(s). Related codes cover unspecified antimicrobial drugs (Z16.30), antiparasitic drug(s) (Z16.31), antifungal drug(s) (Z16.32), antiviral drug(s) (Z16.33), multiple antimicrobial drugs (Z16.35) and other specified antimicrobial drug (Z16.39).

To report this condition, pick the subcode that matches the documentation: Z16.341 (drug) and Z16.342 (drugs).

Code first: the infection.

It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.

Specific codes under Z16.34

Coding notes

Applicable toConditions and synonyms classified to this code
  • Resistance to tuberculostatics

Notes that apply from higher levels

Instructions written at a parent level also apply to Z16.34.

› From Z16.3 Resistance to other antimicrobial drugs
Excludes1
› From Z16 Resistance to antimicrobial drugs
Note
  • The codes in this category are provided for use as additional codes to identify the resistance and non-responsiveness of a condition to antimicrobial drugs.
Excludes1
  • Methicillin resistant Staphylococcus aureus infection (A49.02)
  • Methicillin resistant Staphylococcus aureus pneumonia (J15.212)
  • Sepsis due to Methicillin resistant Staphylococcus aureus (A41.02)
Code first
  • the infection

Broader instructions also apply from Chapter 21: Factors influencing health status and contact with health services.

Code history

  1. 2016
  2. 2017
  3. 2018
  4. 2019
  5. 2020
  6. 2021
  7. 2022
  8. 2023
  9. 2024
  10. 2025
  11. 2026
  12. 2027
  • FY2016 (effective 10/1/2015): Added (first year of ICD-10-CM)
  • No changes since FY2016.

Common questions about Z16.34

Is Z16.34 billable?

No. Z16.34 is a header code. Report one of its more specific subcodes instead.