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ICD-10-CM 2027 diagnosis code

Z51.1Encounter for antineoplastic chemotherapy and immunotherapy

Not billable — use a more specific code

Z51.1 is a header code, so it can't be reported by itself. Choose one of the 2 more specific codes beneath it.

Code unchanged since ICD-10-CM took effect on October 1, 2015. Source: official FY2027 ICD-10-CM release from CDC/NCHS and CMS. Page updated September 29, 2026. About our data

About Z51.1

Z51.1 is the ICD-10-CM diagnosis code for encounter for antineoplastic chemotherapy and immunotherapy. It belongs to category Z51 (encounter for other aftercare and medical care), block Z40-Z53 (Encounters for other specific health care) and chapter 21 (factors influencing health status and contact with health services). It is a header code, so it can't be reported by itself; one of its 2 subcodes must be used instead.

Within Z51 (encounter for other aftercare and medical care), Z51.1 is specifically for encounter for antineoplastic chemotherapy and immunotherapy. Related codes cover antineoplastic radiation therapy (Z51.0), palliative care (Z51.5), desensitization to allergens (Z51.6), other specified aftercare (Z51.8) and sepsis aftercare (Z51.A).

To report this condition, pick the subcode that matches the documentation: Z51.11 (chemotherapy) and Z51.12 (immunotherapy).

The conditions in its Excludes2 note aren't part of Z51.1, but may be coded alongside it if the patient has both: encounter for chemotherapy and immunotherapy for nonneoplastic condition - code to condition.

It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.

Specific codes under Z51.1

Coding notes

Excludes2Not included here — may be reported together if both conditions exist
  • encounter for chemotherapy and immunotherapy for nonneoplastic condition - code to condition

Notes that apply from higher levels

Instructions written at a parent level also apply to Z51.1.

› From Z51 Encounter for other aftercare and medical care
Excludes1
  • follow-up examination after treatment (Z08-Z09)
Code also
  • condition requiring care

Broader instructions also apply from Z40-Z53 Encounters for other specific health care and Chapter 21: Factors influencing health status and contact with health services.

Code history

  1. 2016
  2. 2017
  3. 2018
  4. 2019
  5. 2020
  6. 2021
  7. 2022
  8. 2023
  9. 2024
  10. 2025
  11. 2026
  12. 2027
  • FY2016 (effective 10/1/2015): Added (first year of ICD-10-CM)
  • No changes since FY2016.

Common questions about Z51.1

Is Z51.1 billable?

No. Z51.1 is a header code. Report one of its more specific subcodes instead.