ICD-10-CM 2027
ICD-10 code for agitation
From the official ICD-10-CM alphabetic index entry “Agitation”. Page updated September 29, 2026.
About coding agitation
The ICD-10-CM code for agitation is R45.1 (Restlessness and agitation).
Within R45 (symptoms and signs involving emotional state), R45.1 is specifically for Restlessness and agitation. Related codes cover Nervousness (R45.0), unhappiness (R45.2), Demoralization and apathy (R45.3), irritability and anger (R45.4), Hostility (R45.5), Violent behavior (R45.6), state of emotional shock and stress, unspecified (R45.7) and other symptoms and signs involving emotional state (R45.8).
It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.
In MS-DRG v44.0, it is part of the grouping logic for DRG 884 (Organic Disturbances and Intellectual Disability, relative weight 1.6001), in MDC 19 (Mental Diseases and Disorders), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.
Common questions about agitation ICD-10 codes
What is the ICD-10 code for agitation?
- R45.1 — Restlessness and agitation.
Is R45.1 billable?
- Yes. R45.1 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can R45.1 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict R45.1 as a principal diagnosis.
Is R45.1 a CC or MCC?
- No. R45.1 is neither a CC nor an MCC under MS-DRG v44.0.