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ICD-10-CM 2027

ICD-10 code for ankylosing spondylitis

M45.9

Ankylosing spondylitis of unspecified sites in spine

✓ Billable / specific

Confirmed by the official ICD-10-CM index entry “iridocyclitis › in (due to) › ankylosing spondylitis”. Page updated September 29, 2026.

About coding ankylosing spondylitis

The ICD-10-CM code for ankylosing spondylitis is M45.9 (Ankylosing spondylitis of unspecified sites in spine). The official index lists 19 more specific codes, so check the documentation for details such as type, cause, site or severity before settling on M45.9.

Within M45, choose M45.9 (of unspecified sites in spine) only when documentation doesn't support a more specific option: of multiple sites in spine (M45.0), of occipito-atlanto-axial region (M45.1), of cervical region (M45.2), of cervicothoracic region (M45.3), of thoracic region (M45.4), of thoracolumbar region (M45.5), lumbar region (M45.6), of lumbosacral region (M45.7) and 2 more.

It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.

In MS-DRG v44.0, it is part of the grouping logic for DRG 545 (Connective Tissue Disorders with MCC, relative weight 2.3892), DRG 546 (Connective Tissue Disorders with CC, relative weight 1.1745) and DRG 547 (Connective Tissue Disorders without CC/MCC, relative weight 0.7526), in MDC 08 (Diseases and Disorders of the Musculoskeletal System and Connective Tissue), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.

Related Ankylosing spondylitis codes

  • M45.0 Ankylosing spondylitis of multiple sites in spine
  • M45.1 Ankylosing spondylitis of occipito-atlanto-axial region
  • M45.2 Ankylosing spondylitis of cervical region
  • M45.3 Ankylosing spondylitis of cervicothoracic region
  • M45.4 Ankylosing spondylitis of thoracic region
  • M45.5 Ankylosing spondylitis of thoracolumbar region
  • M45.6 Ankylosing spondylitis lumbar region
  • M45.7 Ankylosing spondylitis of lumbosacral region
  • M45.8 Ankylosing spondylitis sacral and sacrococcygeal region
  • M45.A0 Non-radiographic axial spondyloarthritis of unspecified sites in spine
  • M45.A1 Non-radiographic axial spondyloarthritis of occipito-atlanto-axial region
  • M45.A2 Non-radiographic axial spondyloarthritis of cervical region
  • M45.A3 Non-radiographic axial spondyloarthritis of cervicothoracic region
  • M45.A4 Non-radiographic axial spondyloarthritis of thoracic region
  • M45.A5 Non-radiographic axial spondyloarthritis of thoracolumbar region
  • M45.A6 Non-radiographic axial spondyloarthritis of lumbar region
  • M45.A7 Non-radiographic axial spondyloarthritis of lumbosacral region
  • M45.A8 Non-radiographic axial spondyloarthritis of sacral and sacrococcygeal region
  • M45.AB Non-radiographic axial spondyloarthritis of multiple sites in spine

Common questions about ankylosing spondylitis ICD-10 codes

What is the ICD-10 code for ankylosing spondylitis?

M45.9 — Ankylosing spondylitis of unspecified sites in spine. More specific codes apply when the documentation supports them: M45.0, M45.1, M45.2, M45.3 and others below.

What is the ICD-10 code for ankylosing spondylitis of multiple sites in spine?

M45.0 — Ankylosing spondylitis of multiple sites in spine.

What is the ICD-10 code for ankylosing spondylitis of occipito-atlanto-axial region?

M45.1 — Ankylosing spondylitis of occipito-atlanto-axial region.

What is the ICD-10 code for ankylosing spondylitis of cervical region?

M45.2 — Ankylosing spondylitis of cervical region.

What is the ICD-10 code for ankylosing spondylitis of cervicothoracic region?

M45.3 — Ankylosing spondylitis of cervicothoracic region.

What is the ICD-10 code for ankylosing spondylitis of thoracic region?

M45.4 — Ankylosing spondylitis of thoracic region.

What is the ICD-10 code for ankylosing spondylitis of thoracolumbar region?

M45.5 — Ankylosing spondylitis of thoracolumbar region.

Is M45.9 billable?

Yes. M45.9 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).

Can M45.9 be used as a principal diagnosis?

Yes. The Medicare Code Editor doesn't restrict M45.9 as a principal diagnosis.

Is M45.9 a CC or MCC?

No. M45.9 is neither a CC nor an MCC under MS-DRG v44.0.