ICD-10-CM 2027
ICD-10 code for Argininosuccinic aciduria
From the official ICD-10-CM alphabetic index entry “Aciduria › argininosuccinic”. Page updated September 29, 2026.
About coding Argininosuccinic aciduria
The ICD-10-CM code for Argininosuccinic aciduria is E72.22 (Arginosuccinic aciduria).
Within E72.2 (disorders of urea cycle metabolism), E72.22 is specifically for Arginosuccinic aciduria. Related codes cover disorder of urea cycle metabolism, unspecified (E72.20), Argininemia (E72.21), Citrullinemia (E72.23) and other disorders of urea cycle metabolism (E72.29).
As a secondary diagnosis it is a CC (complication or comorbidity), which can move an inpatient stay into the "with CC" MS-DRG of its family, unless the principal diagnosis excludes it.
In MS-DRG v44.0, it is part of the grouping logic for DRG 642 (Inborn and Other Disorders of Metabolism, relative weight 1.3219), in MDC 10 (Endocrine, Nutritional and Metabolic Diseases and Disorders), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.
Common questions about Argininosuccinic aciduria ICD-10 codes
What is the ICD-10 code for Argininosuccinic aciduria?
- E72.22 — Arginosuccinic aciduria.
Is E72.22 billable?
- Yes. E72.22 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can E72.22 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict E72.22 as a principal diagnosis.
Is E72.22 a CC or MCC?
- E72.22 is a CC (complication or comorbidity) under MS-DRG v44.0, unless excluded by the principal diagnosis.