E72.2Disorders of urea cycle metabolism

E72.2 is the ICD-10-CM diagnosis code for disorders of urea cycle metabolism. It belongs to category E72 (other disorders of amino-acid metabolism), block E70-E88 (metabolic disorders) and chapter 4 (endocrine, nutritional and metabolic diseases). It is a header code, so it can't be reported by itself; one of its 5 subcodes must be used instead.

Within E72 (other disorders of amino-acid metabolism), E72.2 is specifically for disorders of urea cycle metabolism. Related codes cover disorders of amino-acid transport (E72.0), disorders of sulfur-bearing amino-acid metabolism (E72.1), disorders of lysine and hydroxylysine metabolism (E72.3), disorders of ornithine metabolism (E72.4), disorders of glycine metabolism (E72.5), other specified disorders of amino-acid metabolism (E72.8) and disorder of amino-acid metabolism, unspecified (E72.9).

To report this condition, pick the subcode that matches the documentation: E72.20 (unspecified), E72.21 (Argininemia), E72.22 (aciduria), E72.23 (Citrullinemia) and E72.29 (metabolism).

Don't report E72.2 together with the conditions in its Excludes1 note: disorders of ornithine metabolism (E72.4).

It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.