ICD-10-CM 2027
ICD-10 code for central nervous system syphilis
From the official ICD-10-CM alphabetic index entry “Syphilis, syphilitic (acquired) › central nervous system (late) (recurrent) (relapse) (tertiary)”. Page updated September 29, 2026.
About coding central nervous system syphilis
The ICD-10-CM code for central nervous system syphilis is A52.3 (Neurosyphilis, unspecified). The official index lists 16 more specific codes, so check the documentation for details such as type, cause, site or severity before settling on A52.3.
Within A52, choose A52.3 (Neurosyphilis, unspecified) only when documentation doesn't support a more specific option: cardiovascular and cerebrovascular syphilis (A52.0), symptomatic neurosyphilis (A52.1), Asymptomatic neurosyphilis (A52.2), other symptomatic late syphilis (A52.7), latent (A52.8) and unspecified (A52.9).
As a secondary diagnosis it is a CC (complication or comorbidity), which can move an inpatient stay into the "with CC" MS-DRG of its family, unless the principal diagnosis excludes it.
In MS-DRG v44.0, it is part of the grouping logic for DRG 056 (Degenerative Nervous System Disorders with MCC, relative weight 2.2655) and DRG 057 (Degenerative Nervous System Disorders without MCC, relative weight 1.2838), in MDC 01 (Diseases and Disorders of the Nervous System), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.
More specific central nervous system syphilis codes (official index)
- with
- ataxia A52.11 — Tabes dorsalis
- general paralysis A52.17 — General paresis
- juvenile A50.45 — Juvenile general paresis
- paresis (general) A52.17 — General paresis
- juvenile A50.45 — Juvenile general paresis
- tabes (dorsalis) A52.11 — Tabes dorsalis
- juvenile A50.45 — Juvenile general paresis
- taboparesis A52.17 — General paresis
- juvenile A50.45 — Juvenile general paresis
- aneurysm A52.05 — Other cerebrovascular syphilis
- congenital A50.40 — Late congenital neurosyphilis, unspecified
- juvenile A50.40 — Late congenital neurosyphilis, unspecified
- remission in (sustained) A52.3 — Neurosyphilis, unspecified
- serology doubtful, negative, or positive A52.3 — Neurosyphilis, unspecified
- specified nature or site NEC A52.19 — Other symptomatic neurosyphilis
- vascular A52.05 — Other cerebrovascular syphilis
Common questions about central nervous system syphilis ICD-10 codes
What is the ICD-10 code for central nervous system syphilis?
- A52.3 — Neurosyphilis, unspecified. More specific codes apply when the documentation supports them: A52.11, A52.17, A50.45, A52.17 and others below.
What is the ICD-10 code for aneurysm central nervous system syphilis?
- A52.05 — Other cerebrovascular syphilis.
What is the ICD-10 code for congenital central nervous system syphilis?
- A50.40 — Late congenital neurosyphilis, unspecified.
What is the ICD-10 code for juvenile central nervous system syphilis?
- A50.40 — Late congenital neurosyphilis, unspecified.
What is the ICD-10 code for remission in central nervous system syphilis?
- A52.3 — Neurosyphilis, unspecified.
What is the ICD-10 code for vascular central nervous system syphilis?
- A52.05 — Other cerebrovascular syphilis.
Is A52.3 billable?
- Yes. A52.3 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can A52.3 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict A52.3 as a principal diagnosis.
Is A52.3 a CC or MCC?
- A52.3 is a CC (complication or comorbidity) under MS-DRG v44.0, unless excluded by the principal diagnosis.