A52.3Neurosyphilis, unspecified

A52.3 is the ICD-10-CM diagnosis code for neurosyphilis, unspecified. It belongs to category A52 (late syphilis), block A50-A64 (infections with a predominantly sexual mode of transmission) and chapter 1 (certain infectious and parasitic diseases). It is billable, so it can be reported on its own for dates of service from October 1, 2026 through September 30, 2027.

Within A52, choose A52.3 (Neurosyphilis, unspecified) only when documentation doesn't support a more specific option: cardiovascular and cerebrovascular syphilis (A52.0), symptomatic neurosyphilis (A52.1), Asymptomatic neurosyphilis (A52.2), other symptomatic late syphilis (A52.7), latent (A52.8) and unspecified (A52.9).

As a secondary diagnosis it is a CC (complication or comorbidity), which can move an inpatient stay into the "with CC" MS-DRG of its family, unless the principal diagnosis excludes it.

In MS-DRG v44.0, it is part of the grouping logic for DRG 056 (Degenerative Nervous System Disorders with MCC, relative weight 2.2655) and DRG 057 (Degenerative Nervous System Disorders without MCC, relative weight 1.2838), in MDC 01 (Diseases and Disorders of the Nervous System), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.

It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.

Before ICD-10, this condition was coded in ICD-9-CM as 094.9 (neurosyphilis, unspecified).