ICD-10-CM 2027
ICD-10 code for cryptococcosis
From the official ICD-10-CM alphabetic index entry “Cryptococcosis, cryptococcus (infection) (neoformans)”. Page updated September 29, 2026.
About coding cryptococcosis
The ICD-10-CM code for cryptococcosis is B45.9 (Cryptococcosis, unspecified). The official index lists 11 more specific codes, so check the documentation for details such as type, cause, site or severity before settling on B45.9.
Within B45, choose B45.9 (unspecified) only when documentation doesn't support a more specific option: pulmonary cryptococcosis (B45.0), cerebral cryptococcosis (B45.1), cutaneous cryptococcosis (B45.2), osseous cryptococcosis (B45.3), disseminated cryptococcosis (B45.7) and other forms of cryptococcosis (B45.8).
As a secondary diagnosis it is a CC (complication or comorbidity), which can move an inpatient stay into the "with CC" MS-DRG of its family, unless the principal diagnosis excludes it.
In MS-DRG v44.0, it is part of the grouping logic for DRG 791 (Prematurity with Major Problems, relative weight 4.1075), DRG 793 (Full Term Neonate with Major Problems, relative weight 4.2195), DRG 867 (Other Infectious and Parasitic Diseases Diagnoses with MCC, relative weight 2.1859), DRG 868 (Other Infectious and Parasitic Diseases Diagnoses with CC, relative weight 1.0235), DRG 869 (Other Infectious and Parasitic Diseases Diagnoses without CC/MCC, relative weight 0.6787), DRG 974 (HIV with Major Related Condition with MCC, relative weight 3.0506) and 2 more, in MDC 15 (Newborns and Other Neonates with Conditions Originating in the Perinatal Period), MDC 18 (Infectious and Parasitic Diseases, Systemic or Unspecified Sites) and MDC 25 (Human Immunodeficiency Virus Infections), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.
More specific cryptococcosis codes (official index)
- bone B45.3 — Osseous cryptococcosis
- cerebral B45.1 — Cerebral cryptococcosis
- cutaneous B45.2 — Cutaneous cryptococcosis
- disseminated B45.7 — Disseminated cryptococcosis
- generalized B45.7 — Disseminated cryptococcosis
- meningitis B45.1 — Cerebral cryptococcosis
- meningocerebralis B45.1 — Cerebral cryptococcosis
- osseous B45.3 — Osseous cryptococcosis
- pulmonary B45.0 — Pulmonary cryptococcosis
- skin B45.2 — Cutaneous cryptococcosis
- specified NEC B45.8 — Other forms of cryptococcosis
Common questions about cryptococcosis ICD-10 codes
What is the ICD-10 code for cryptococcosis?
- B45.9 — Cryptococcosis, unspecified. More specific codes apply when the documentation supports them: B45.3, B45.1, B45.2, B45.7 and others below.
What is the ICD-10 code for bone cryptococcosis?
- B45.3 — Osseous cryptococcosis.
What is the ICD-10 code for cerebral cryptococcosis?
- B45.1 — Cerebral cryptococcosis.
What is the ICD-10 code for cutaneous cryptococcosis?
- B45.2 — Cutaneous cryptococcosis.
What is the ICD-10 code for disseminated cryptococcosis?
- B45.7 — Disseminated cryptococcosis.
What is the ICD-10 code for generalized cryptococcosis?
- B45.7 — Disseminated cryptococcosis.
What is the ICD-10 code for meningitis cryptococcosis?
- B45.1 — Cerebral cryptococcosis.
Is B45.9 billable?
- Yes. B45.9 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can B45.9 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict B45.9 as a principal diagnosis.
Is B45.9 a CC or MCC?
- B45.9 is a CC (complication or comorbidity) under MS-DRG v44.0, unless excluded by the principal diagnosis.