ICD-10-CM 2027
ICD-10 code for Cryptogenic sepsis
From the official ICD-10-CM alphabetic index entry “Sepsis (generalized) (unspecified organism) › cryptogenic”. Page updated September 29, 2026.
About coding Cryptogenic sepsis
The ICD-10-CM code for Cryptogenic sepsis is A41.9 (Sepsis, unspecified organism).
Within A41, choose A41.9 (Sepsis, unspecified organism) only when documentation doesn't support a more specific option: sepsis due to Staphylococcus aureus (A41.0), sepsis due to other specified staphylococcus (A41.1), sepsis due to unspecified staphylococcus (A41.2), sepsis due to Hemophilus influenzae (A41.3), sepsis due to anaerobes (A41.4), sepsis due to other Gram-negative organisms (A41.5) and other specified sepsis (A41.8).
Code first: , if applicable, postprocedural sepsis (T81.44-), sepsis due to central venous catheter (T80.211-), sepsis during labor (O75.3), sepsis following abortion, ectopic or molar pregnancy (O03.37, O03.87, O04.87, O07.37, O08.82) and 2 more.
As a secondary diagnosis it is an MCC (major complication or comorbidity), which can move an inpatient stay into the highest-paying "with MCC" MS-DRG of its family, unless the principal diagnosis excludes it.
Common questions about Cryptogenic sepsis ICD-10 codes
What is the ICD-10 code for Cryptogenic sepsis?
- A41.9 — Sepsis, unspecified organism.
Is A41.9 billable?
- Yes. A41.9 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can A41.9 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict A41.9 as a principal diagnosis.
Is A41.9 a CC or MCC?
- A41.9 is an MCC (major complication or comorbidity) under MS-DRG v44.0, unless excluded by the principal diagnosis.