ICD-10-CM 2027
ICD-10 code for Danon disease
Lysosome-associated membrane protein 2 [LAMP2] deficiency
From the official ICD-10-CM alphabetic index entry “Disease, diseased › Danon”. Page updated September 29, 2026.
About coding Danon disease
The ICD-10-CM code for Danon disease is E74.05 (Lysosome-associated membrane protein 2 [LAMP2] deficiency).
Within E74.0 (glycogen storage disease), E74.05 is specifically for Lysosome-associated membrane protein 2 [LAMP2] deficiency. Related codes cover unspecified (E74.00), von Gierke disease (E74.01), Pompe disease (E74.02), Cori disease (E74.03), McArdle disease (E74.04) and other glycogen storage disease (E74.09).
As a secondary diagnosis it is a CC (complication or comorbidity), which can move an inpatient stay into the "with CC" MS-DRG of its family, unless the principal diagnosis excludes it.
In MS-DRG v44.0, it is part of the grouping logic for DRG 642 (Inborn and Other Disorders of Metabolism, relative weight 1.3219), in MDC 10 (Endocrine, Nutritional and Metabolic Diseases and Disorders), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.
Common questions about Danon disease ICD-10 codes
What is the ICD-10 code for Danon disease?
- E74.05 — Lysosome-associated membrane protein 2 [LAMP2] deficiency.
Is E74.05 billable?
- Yes. E74.05 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can E74.05 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict E74.05 as a principal diagnosis.
Is E74.05 a CC or MCC?
- E74.05 is a CC (complication or comorbidity) under MS-DRG v44.0, unless excluded by the principal diagnosis.