ICD-10-CM 2027
ICD-10 code for factor V Leiden mutation
From the official ICD-10-CM alphabetic index entry “Mutation (s) › factor V Leiden”. Page updated September 29, 2026.
About coding factor V Leiden mutation
The ICD-10-CM code for factor V Leiden mutation is D68.51 (Activated protein C resistance).
Within D68.5 (primary thrombophilia), D68.51 is specifically for activated protein C resistance. Related codes cover Prothrombin gene mutation (D68.52) and other primary thrombophilia (D68.59).
As a secondary diagnosis it is a CC (complication or comorbidity), which can move an inpatient stay into the "with CC" MS-DRG of its family, unless the principal diagnosis excludes it.
In MS-DRG v44.0, it is part of the grouping logic for DRG 814 (Reticuloendothelial and Immunity Disorders with MCC, relative weight 2.0729), DRG 815 (Reticuloendothelial and Immunity Disorders with CC, relative weight 1.0444) and DRG 816 (Reticuloendothelial and Immunity Disorders without CC/MCC, relative weight 0.7381), in MDC 16 (Diseases and Disorders of the Blood and Blood Forming Organs and Immunological Disorders), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.
Common questions about factor V Leiden mutation ICD-10 codes
What is the ICD-10 code for factor V Leiden mutation?
- D68.51 — Activated protein C resistance.
Is D68.51 billable?
- Yes. D68.51 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can D68.51 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict D68.51 as a principal diagnosis.
Is D68.51 a CC or MCC?
- D68.51 is a CC (complication or comorbidity) under MS-DRG v44.0, unless excluded by the principal diagnosis.