D68.5Primary thrombophilia

D68.5 is the ICD-10-CM diagnosis code for primary thrombophilia. It belongs to category D68 (other coagulation defects), block D65-D69 (coagulation defects, purpura and other hemorrhagic conditions) and chapter 3 (diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism). It is a header code, so it can't be reported by itself; one of its 3 subcodes must be used instead.

Within D68 (other coagulation defects), D68.5 is specifically for primary thrombophilia. Related codes cover von Willebrand disease (D68.0), hereditary factor XI deficiency (D68.1), hereditary deficiency of other clotting factors (D68.2), hemorrhagic disorder due to circulating anticoagulants (D68.3), acquired coagulation factor deficiency (D68.4), other thrombophilia (D68.6), other specified coagulation defects (D68.8) and coagulation defect, unspecified (D68.9).

To report this condition, pick the subcode that matches the documentation: D68.51 (resistance), D68.52 (mutation) and D68.59 (thrombophilia).

Don't report D68.5 together with the conditions in its Excludes1 note: antiphospholipid syndrome (D68.61), lupus anticoagulant (D68.62), secondary activated protein C resistance (D68.69), secondary antiphospholipid antibody syndrome (D68.69) and 5 more.

It has been part of ICD-10-CM since the code set took effect on October 1, 2015 and hasn't changed since.