ICD-10-CM 2027
ICD-10 code for FPIES
From the official ICD-10-CM alphabetic index entry “FPIES (food protein-induced enterocolitis syndrome)”. Page updated September 29, 2026.
About coding FPIES
The ICD-10-CM code for FPIES is K52.21 (Food protein-induced enterocolitis syndrome).
Within K52.2 (allergic and dietetic gastroenteritis and colitis), K52.21 is specifically for food protein-induced enterocolitis syndrome. Related codes cover food protein-induced enteropathy (K52.22) and other allergic and dietetic gastroenteritis and colitis (K52.29).
Use an additional code for hypovolemic shock, if present (R57.1).
It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.
Common questions about FPIES ICD-10 codes
What is the ICD-10 code for FPIES?
- K52.21 — Food protein-induced enterocolitis syndrome.
Is K52.21 billable?
- Yes. K52.21 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can K52.21 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict K52.21 as a principal diagnosis.
Is K52.21 a CC or MCC?
- No. K52.21 is neither a CC nor an MCC under MS-DRG v44.0.