ICD-10-CM 2027
ICD-10 code for fructose intolerance
From the official ICD-10-CM alphabetic index entry “Intolerance › fructose”. Page updated September 29, 2026.
About coding fructose intolerance
The ICD-10-CM code for fructose intolerance is E74.10 (Disorder of fructose metabolism, unspecified). The official index lists 1 more specific code, so check the documentation for details such as type, cause, site or severity before settling on E74.10.
Within E74.1, choose E74.10 (Disorder of fructose metabolism, unspecified) only when documentation doesn't support a more specific option: essential fructosuria (E74.11), hereditary fructose intolerance (E74.12) and other disorders of fructose metabolism (E74.19).
It is not a CC or MCC, so as a secondary diagnosis it doesn't change the MS-DRG severity level.
In MS-DRG v44.0, it is part of the grouping logic for DRG 391 (Esophagitis, Gastroenteritis and Miscellaneous Digestive Disorders with MCC, relative weight 1.2392) and DRG 392 (Esophagitis, Gastroenteritis and Miscellaneous Digestive Disorders without MCC, relative weight 0.7645), in MDC 06 (Diseases and Disorders of the Digestive System), as a principal or secondary diagnosis. The DRG a claim lands in depends on the principal diagnosis, procedures and any CC/MCC secondary diagnoses.
More specific fructose intolerance codes (official index)
- hereditary E74.12 — Hereditary fructose intolerance
Common questions about fructose intolerance ICD-10 codes
What is the ICD-10 code for fructose intolerance?
- E74.10 — Disorder of fructose metabolism, unspecified. More specific codes apply when the documentation supports them: E74.12.
What is the ICD-10 code for hereditary fructose intolerance?
- E74.12 — Hereditary fructose intolerance.
Is E74.10 billable?
- Yes. E74.10 is a billable/specific ICD-10-CM code valid for FY2027 (October 1, 2026 – September 30, 2027).
Can E74.10 be used as a principal diagnosis?
- Yes. The Medicare Code Editor doesn't restrict E74.10 as a principal diagnosis.
Is E74.10 a CC or MCC?
- No. E74.10 is neither a CC nor an MCC under MS-DRG v44.0.